Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX15 | P16050 | 12/20 | 0.65 |
| ▸ | GRM4 | Q14833 | 1/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.47 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | TP53 | P04637 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4202584 | 0.87 | RAB9A (0.51) | ALOX15NPSR1CYP1A2CYP3A4CYP2C19 | |
| SCHEMBL4198230 | 0.85 | ALOX15 (0.63) | ALOX15NPSR1CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL169574 | 0.84 | ALOX15 (0.47) | ALOX15CYP1A2CYP2C19LMNATP53 | |
| SCHEMBL4205361 | 0.83 | RAB9A (0.56) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL29198676 | 0.82 | CHRM3 (0.46) | ALOX15 | |
| SCHEMBL30917977 | 0.82 | CHRM3 (0.46) | ALOX15 | |
| SCHEMBL4201444 | 0.82 | ALOX15 (0.51) | ALOX15GRM4CYP1A2CYP2C19LMNA | |
| SCHEMBL4188965 | 0.82 | MEN1 (0.45) | ALOX15CYP1A2CYP3A4CYP2C9CYP2C19 | |
| SCHEMBL4252112 | 0.80 | ALOX15 (0.78) | ALOX15GRM4CYP1A2CYP3A4CYP2C9 | |
| SCHEMBL4250359 | 0.79 | ALOX15 (0.63) | ALOX15GRM4NPSR1CYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090247634-A1 | Methods for identifying modulators of eoxin formation | CLAESSON HANS-ERIK | 2009-10-01 | — | — | US | disclosed |
| US-20090088463-A1 | Pyrazoles Useful in the Treatment of Inflammation | BIOLIPOX AB (SE) | 2009-04-02 | — | — | US | disclosed |
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | BIOLIPOX AB (SE) | 2006-08-17 | — | — | US | disclosed |
| EP-1603897-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | Biolipox AB (SE) | 2005-12-14 | — | — | EP | disclosed |
| WO-2004080999-A1 | PYRAZOLE COMPOUNDS USEFUL IN THE TREATMENT OF INFLAMMATION | BIOLIPOX AB (SE) | 2004-09-23 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090088463-A1 | Pyrazoles Useful in the Treatment of Inflammation | ALOX15, ALOX5, ALOX15B | ALOX15 1/4885GRM4 2507/4885NPSR1 1568/4885 |
| US-20090247634-A1 | Methods for identifying modulators of eoxin formation | LTA4H, LTC4S, LTB4R2 | ALOX15 8/4885GRM4 385/4885NPSR1 1736/4885 |
| US-20060183780-A1 | Pyrazole compounds useful in the treatment of inflammation | ALOX15, ALOX12, ALOX15B | ALOX15 1/4885GRM4 2581/4885NPSR1 1111/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.