Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA12 | O43570 | 3/20 | 0.42 |
| ▸ | CA1 | P00915 | 3/20 | 0.42 |
| ▸ | CA2 | P00918 | 3/20 | 0.42 |
| ▸ | CA4 | P22748 | 3/20 | 0.42 |
| ▸ | CA9 | Q16790 | 3/20 | 0.42 |
| ▸ | NOD1 | Q9Y239 | 2/20 | 0.40 |
| ▸ | PTGS2 | P35354 | 3/20 | 0.39 |
| ▸ | SLC15A1 | P46059 | 1/20 | 0.35 |
| ▸ | ESR1 | P03372 | 1/20 | 0.33 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.33 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.33 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.33 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.33 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.33 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.33 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.33 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.33 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL168158 | 1.00 | CA12 (0.42) | CA12CA1CA2CA4CA9 | |
| SCHEMBL15359687 | 0.91 | NOD1 (0.46) | CA12CA1CA2CA4CA9 | |
| SCHEMBL166321 | 0.90 | PTGS2 (0.39) | CA12CA1CA2CA4CA9 | |
| SCHEMBL166023 | 0.90 | PTGS2 (0.39) | CA12CA1CA2CA4CA9 | |
| SCHEMBL16124746 | 0.85 | NOD1 (0.47) | NOD1NAAA | |
| SCHEMBL13396346 | 0.84 | CA12 (0.39) | CA12CA1CA2CA4CA9 | |
| SCHEMBL16124743 | 0.83 | NOD1 (0.40) | CA12CA1CA2CA4CA9 | |
| SCHEMBL13396340 | 0.83 | GSR (0.43) | CA12CA1CA2CA4CA9 | |
| SCHEMBL3398534 | 0.83 | GRM8 (0.42) | CA12CA1CA2CA4CA9 | |
| SCHEMBL6516893 | 0.83 | CA12 (0.41) | CA12CA1CA2CA4CA9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 48 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150202175-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | FARBER MICHAEL (US) | 2015-07-23 | — | — | US | claimed |
| US-20150093338-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | FARBER MICHAEL (US) | 2015-04-02 | — | — | US | claimed |
| US-8946160-B2 | Nitric oxide amino acid esters for improving vascular circulation, and prophylaxis or treatment of a condition associated with impaired blood circulation | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2015-02-03 | — | — | US | claimed |
| US-8883844-B2 | Nitric oxide releasing amino acid ester for treatment of pulmonary hypertension and other respiratory conditions | NITROGENIX INC. (VG) | 2014-11-11 | — | — | US | claimed |
| US-20140148438-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NITROGENIX, INC. (VG) | 2014-05-29 | — | — | US | claimed |
| US-20130287866-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2013-10-31 | — | — | US | claimed |
| EP-2632453-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR IMPROVING VASCULAR CIRCULATION, AND PROPHYLAXIS OR TREATMENT OF A CONDITION ASSOCIATED WITH IMPAIRED BLOOD CIRCULATION | Oral Delivery Technology Ltd. (CA) | 2013-09-04 | — | — | EP | claimed |
| WO-2012079146-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR IMPROVING VASCULAR CIRCULATION, AND PROPHYLAXIS OR TREATMENT OF A CONDITION ASSOCIATED WITH IMPAIRED BLOOD CIRCULATION | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2012-06-21 | — | — | WO | claimed |
| WO-2012037665-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2012-03-29 | — | — | WO | claimed |
| WO-2011057387-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | ORAL DELIVERY TECHNOLOGY LTD . (CA) | 2011-05-19 | — | — | WO | claimed |
| WO-2011057386-A1 | COMPOSITION AND PROPHYLACTIC DEVICE FOR ENHANCING SEXUAL PERFORMANCE OR PLEASURE | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2011-05-19 | — | — | WO | claimed |
| US-20170105959-A1 | COMPOSITIONS CONTAINING NITRIC OXIDE AMINO ACID ESTERS AND METHODS FOR IMPROVING SEXUAL PERFORMANCE | SMARTEK INTERNATIONAL, INC. | 2017-04-20 | — | — | US | disclosed |
| US-20170105959-A1 | COMPOSITIONS CONTAINING NITRIC OXIDE AMINO ACID ESTERS AND METHODS FOR IMPROVING SEXUAL PERFORMANCE | SMARTEK INTERNATIONAL, INC. | 2017-04-20 | — | — | US | disclosed |
| US-20170105959-A1 | COMPOSITIONS CONTAINING NITRIC OXIDE AMINO ACID ESTERS AND METHODS FOR IMPROVING SEXUAL PERFORMANCE | SMARTEK INTERNATIONAL, INC. | 2017-04-20 | — | — | US | disclosed |
| US-20150202175-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | FARBER MICHAEL (US) | 2015-07-23 | — | — | US | disclosed |
| WO-2011057387-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | ORAL DELIVERY TECHNOLOGY LTD . (CA) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011057387-A1 | NITRIC OXIDE AMINO ACID ESTERS FOR THE TREATMENT OF CHRONIC PAIN | ORAL DELIVERY TECHNOLOGY LTD . (CA) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011057386-A1 | COMPOSITION AND PROPHYLACTIC DEVICE FOR ENHANCING SEXUAL PERFORMANCE OR PLEASURE | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011057386-A1 | COMPOSITION AND PROPHYLACTIC DEVICE FOR ENHANCING SEXUAL PERFORMANCE OR PLEASURE | ORAL DELIVERY TECHNOLOGY LTD. (CA) | 2011-05-19 | — | — | WO | disclosed |
| WO-2011041870-A1 | NON-STEROIDAL ANTI-INFLAMMATORY DRUGS COADMINISTERED WITH NITRIC OXIDE AMINO ACID ESTER COMPOUNDS AS PROPHYLAXIS IN HYPERTENSIVE PATIENTS | NITROGENIX INC. (VG) | 2011-04-14 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150202175-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | NOS1, NOS2, NOS3 | CA12 3029/4885CA1 2229/4885CA2 1334/4885 |
| US-20130287866-A1 | Nitric Oxide Amino Acid Esters for Improving Vascular Circulation, and Prophylaxis or Treatment of a Condition Associated with Impaired Blood Circulation | NOS1, NOS2, NOS3 | CA12 2316/4885CA1 2116/4885CA2 1136/4885 |
| US-20140148438-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NOS2, NOS1, NOS3 | CA12 2305/4885CA1 2425/4885CA2 440/4885 |
| US-20150093338-A1 | NITRIC OXIDE RELEASING AMINO ACID ESTER FOR TREATMENT OF PULMONARY HYPERTENSION AND OTHER RESPIRATORY CONDITIONS | NOS2, NOS1, NOS3 | CA12 2305/4885CA1 2425/4885CA2 440/4885 |
| US-20170105959-A1 | COMPOSITIONS CONTAINING NITRIC OXIDE AMINO ACID ESTERS AND METHODS FOR IMPROVING SEXUAL PERFORMANCE | NOS1, NOS2, NOS3 | CA12 4112/4885CA1 2920/4885CA2 2659/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.