Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 2/20 | 0.54 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.51 |
| ▸ | PTGES | O14684 | 1/20 | 0.48 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | GCGR | P47871 | 1/20 | 0.45 |
| ▸ | PRKCZ | Q05513 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | ALPL | P05186 | 1/20 | 0.42 |
| ▸ | TARBP2 | Q15633 | 1/20 | 0.42 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16972721 | 0.88 | TP53 (0.56) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL16568257 | 0.87 | TP53 (0.55) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL14740959 | 0.74 | SERPINE1 (0.47) | TP53MDM2ALOX5PTGESALDH1A1 | |
| SCHEMBL8036853 | 0.72 | SIRT2 (0.54) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL8026733 | 0.72 | SIRT2 (0.56) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL32688181 | 0.71 | ALDH1A1 (0.65) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL5023315 | 0.71 | ALPL (0.55) | TP53MDM2ALOX5GCGRALPL | |
| SCHEMBL11273877 | 0.70 | CSF1R (0.49) | TP53MDM2ALOX5CSF1RPRKCZ | |
| SCHEMBL8515925 | 0.70 | ALOX5 (0.64) | TP53MDM2ALOX5PTGESCSF1R | |
| SCHEMBL10463192 | 0.69 | ALOX5 (0.56) | TP53MDM2ALOX5PRKCZALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015114317-A1 | 5H-ISOTHIAZOLO[4,5-C]PYRIDINE-3,4-DIONE OR 5H-PYRAZOLO[4,3-C]PYRIDIN-3,4-DIONE AS ANTIBACTERIAL COMPOUNDS | REDX PHARMA PLC (GB) | 2015-08-06 | — | — | WO | disclosed |