Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 10/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | OPRD1 | P41143 | 6/20 | 0.38 |
| ▸ | OPRK1 | P41145 | 5/20 | 0.38 |
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | MRGPRX2 | Q96LB1 | 2/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.35 |
| ▸ | MTOR | P42345 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.35 |
| ▸ | THPO | P40225 | 1/20 | 0.35 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29401440 | 1.00 | OPRM1 (0.39) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL29900519 | 0.96 | OPRM1 (0.37) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL3264817 | 0.96 | OPRM1 (0.37) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL2003721 | 0.96 | OPRM1 (0.37) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL9328056 | 0.93 | OPRM1 (0.35) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| Bicarbonate SCHEMBL7804013 | 0.93 | CYP3A4 (0.41) | OPRM1CYP3A4ALDH1A1LMNA | |
| SCHEMBL18415542 | 0.93 | MAPT (0.39) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL237708 | 0.92 | OPRM1 (0.39) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL29914192 | 0.92 | OPRM1 (0.39) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 | |
| SCHEMBL13318036 | 0.91 | ACHE (0.35) | OPRM1CYP3A4ALDH1A1LMNAOPRD1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1406 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11866393-B2 | 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and preparation method thereof | ZHEJIANG UNIVERSITY (CN) | 2024-01-09 | — | — | US | claimed |
| EP-3650482-B1 | POLYCARBONATE COPOLYMER | TEIJIN LTD (JP) | 2023-01-11 | — | — | EP | claimed |
| CN-114957276-A | Active ester curing agent and preparation method thereof, epoxy resin composition, composite film and application thereof | 深圳先进电子材料国际创新研究院 | 2022-08-30 | — | — | CN | claimed |
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2022-07-07 | — | — | US | claimed |
| US-11198759-B2 | Polycarbonate copolymer | TEIJIN LIMITED (JP) | 2021-12-14 | — | — | US | claimed |
| CN-108463484-B | Thermoplastic polyimides, methods for making same, and articles made therefrom | 沙特基础工业全球技术有限公司 | 2021-06-08 | — | — | CN | claimed |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ZHEJIANG UNIVERSITY (CN) | 2021-06-03 | — | — | US | claimed |
| US-20200283571-A1 | POLYCARBONATE COPOLYMER | TEIJIN LIMITED (JP) | 2020-09-10 | — | — | US | claimed |
| EP-3575340-B1 | POLYCARBONATE COPOLYMER | TEIJIN LTD (JP) | 2020-07-15 | — | — | EP | claimed |
| EP-3650482-A1 | POLYCARBONATE COPOLYMER | Teijin Limited (JP) | 2020-05-13 | — | — | EP | claimed |
| EP-0192480-B1 | Bis(3-aminophenoxy) aromatics and method of preparing the same | MITSUI TOATSU CHEMICALS (JP) | 1994-11-23 | — | — | EP | claimed |
| EP-0471703-A1 | POLYARLYLETHER KETONES CONTAINING INDANE AND USE OF AMORPHOUS POLYARLYETHER KETONES IN OPTICAL SYSTEMS | HOECHST AKTIENGESELLSCHAFT (DE) | 1992-02-26 | — | — | EP | claimed |
| US-5077436-A | Reacting dihydroxy derivatives with m-dinitrobenzene; reducing | MITSUI TOATSU CHEMICALS, INC. (JP) | 1991-12-31 | — | — | US | claimed |
| EP-0264026-B1 | SUBSTANTIALLY PURE SPIROBIINDANE BISPHENOLS AND METHOD FOR THEIR PREPARATION | GENERAL ELECTRIC COMPANY (US) | 1991-03-06 | — | — | EP | claimed |
| WO-1990014378-A1 | POLYARLYLETHER KETONES CONTAINING INDANE AND USE OF AMORPHOUS POLYARLYETHER KETONES IN OPTICAL SYSTEMS | HOECHST AKTIENGESELLSCHAFT (DE) | 1990-11-29 | — | — | WO | claimed |
| US-4791234-A | REACTING BISPHENOL OR ISOPROPENYLPHENOL WITH ACIDIC CATALYST, REMOVING BY-PRODUCTS, PRECIPITATION WITH WATER FROM SOLVENT MIXTURE | GENERAL ELECTRIC COMPANY (US) | 1988-12-13 | — | — | US | claimed |
| US-4701567-A | HEATING BISPHENOL A IN PRESENCE OF ACID CATALYST | MITSUI TOATSU CHEMICALS, INC. (JP) | 1987-10-20 | — | — | US | claimed |
| EP-0192480-A1 | Bis(3-aminophenoxy) aromatics and method of preparing the same | MITSUI TOATSU CHEMICALS, Inc. (JP) | 1986-08-27 | — | — | EP | claimed |
| US-4605726-A | BASED ON A 1,1'-SPIROBIINDANE-6,6'-DIOL; HEAT RESISTANCE; ENGINEERING THERMOPLASTICS | GENERAL ELECTRIC COMPANY (US) | 1986-08-12 | — | — | US | claimed |
| US-4552949-A | Polycarbonate of spiro dihydric phenol | GENERAL ELECTRIC COMPANY (US) | 1985-11-12 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20220213011-A1 | 7,7'-DIHALO-3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE AND PREPARATION METHOD THEREOF | TALDO1, REN, PKD1 | OPRM1 326/4885CYP3A4 954/4885ALDH1A1 123/4885 |
| US-11866393-B2 | 7,7′-dihalo-3,3,3′,3′-tetramethyl-1,1′-spirobiindane and preparation method thereof | TALDO1, REN, PKD1 | OPRM1 333/4885CYP3A4 955/4885ALDH1A1 123/4885 |
| US-20210163514-A1 | COMPOUND OF 3,3,3',3'-TETRAMETHYL-1,1'-SPIROBIINDANE-BASED PHOSPHINE LIGAND, AND PREPARATION METHOD THEREOF | ORMDL3, TALDO1, TAC3 | OPRM1 93/4885CYP3A4 1623/4885ALDH1A1 202/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.