Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR3A | P46098 | 4/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | GLA | P06280 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | HRH4 | Q9H3N8 | 4/20 | 0.38 |
| ▸ | CHEK1 | O14757 | 3/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.38 |
| ▸ | HTR6 | P50406 | 1/20 | 0.38 |
| ▸ | HTR3E | A5X5Y0 | 1/20 | 0.36 |
| ▸ | HTR3B | O95264 | 1/20 | 0.36 |
| ▸ | HTR3D | Q70Z44 | 1/20 | 0.36 |
| ▸ | HTR3C | Q8WXA8 | 1/20 | 0.36 |
| ▸ | PIM1 | P11309 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21451017 | 0.83 | KMT2A (0.41) | HTR3AKDM4EHRH4ALDH1A1MEN1 | |
| SCHEMBL13605183 | 0.70 | HRH4 (0.50) | HTR3AHRH4MEN1KMT2AHTR3E | |
| SCHEMBL4505999 | 0.70 | KDM4E (0.43) | KDM4EHTTALDH1A1MEN1KMT2A | |
| SCHEMBL8215737 | 0.70 | PTGS2 (0.40) | KDM4EHTTALDH1A1MEN1KMT2A | |
| SCHEMBL17794220 | 0.70 | HRH4 (0.50) | HTR3AKDM4EHRH4ALDH1A1MEN1 | |
| SCHEMBL170375 | 0.69 | — | — | |
| SCHEMBL31078509 | 0.68 | PIM2 (0.47) | HTR3AKDM4EHRH4CHEK1ALDH1A1 | |
| SCHEMBL2638000 | 0.68 | HTR3A (0.58) | HTR3AKDM4EHRH4ALDH1A1MEN1 | |
| SCHEMBL17373753 | 0.68 | GSK3B (0.45) | KDM4EGLAHTTCHEK1ALDH1A1 | |
| Water SCHEMBL2643978 | 0.67 | HCAR2 (0.41) | KDM4EALDH1A1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10358443-B2 | Heteroaryl amides as inhibitors of protein aggregation | UCB BIOPHARMA SPRL (BE) | 2019-07-23 | — | — | US | disclosed |
| US-20180093979-A1 | HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | NEUROPORE THERAPIES, INC. (US) | 2018-04-05 | — | — | US | disclosed |
| EP-3099684-B1 | HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | NEUROPORE THERAPIES INC (US) | 2018-04-04 | — | — | EP | disclosed |
| US-9738635-B2 | Heteroaryl amides as inhibitors of protein aggregation | NEUROPORE THERAPIES, INC. (US) | 2017-08-22 | — | — | US | disclosed |
| US-20160207912-A1 | HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | UCB BIOPHARMA SPRL (BE) | 2016-07-21 | — | — | US | disclosed |
| WO-2015116663-A1 | HETEROARLY AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | NEUROPORE THERAPIES, INC. (US) | 2015-08-06 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20180093979-A1 | HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | HTT, PARK7, UACA | HTR3A 445/4885KDM4E 1702/4885GLA 908/4885 |
| US-10358443-B2 | Heteroaryl amides as inhibitors of protein aggregation | HTT, PARK7, UACA | HTR3A 445/4885KDM4E 1702/4885GLA 908/4885 |
| US-20160207912-A1 | HETEROARYL AMIDES AS INHIBITORS OF PROTEIN AGGREGATION | HTT, PARK7, UACA | HTR3A 445/4885KDM4E 1702/4885GLA 908/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.