Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGS2 | P35354 | 1/20 | 0.40 |
| ▸ | PRKDC | P78527 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | GAA | P10253 | 2/20 | 0.39 |
| ▸ | PIK3R1 | P27986 | 1/20 | 0.39 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | MAPT | P10636 | 2/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.38 |
| ▸ | TSHR | P16473 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.37 |
| ▸ | HTT | P42858 | 2/20 | 0.37 |
| ▸ | PDE2A | O00408 | 1/20 | 0.37 |
| ▸ | KMO | O15229 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 3/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14334236 | 0.72 | KMT2A (0.43) | PTGS2PRKDCMEN1KMT2AGAA | |
| SCHEMBL18619678 | 0.69 | LMNA (0.55) | LMNA | |
| SCHEMBL9762614 | 0.69 | POLB (0.49) | MEN1KMT2AALDH1A1MAPTTP53 | |
| SCHEMBL8216543 | 0.69 | PIK3CA (0.41) | PTGS2PRKDCMEN1KMT2AGAA | |
| SCHEMBL12734079 | 0.69 | IRAK4 (0.53) | PTGS2GAAPIK3CAALDH1A1HSD17B10 | |
| SCHEMBL1204641 | 0.68 | — | — | |
| SCHEMBL25877128 | 0.68 | PIK3CA (0.48) | PTGS2PIK3R1PIK3CAHSD17B10PIK3CB | |
| SCHEMBL24766030 | 0.67 | KMT2A (0.47) | MEN1KMT2AGAAPIK3CAALDH1A1 | |
| SCHEMBL1069005 | 0.67 | CNR2 (0.55) | MEN1KMT2APIK3CAALDH1A1MAPT | |
| SCHEMBL18412787 | 0.67 | ALDH1A1 (0.49) | MEN1KMT2AGAAPIK3CAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2000023444-A1 | 5,7-DISUBSTITUTED-4-AMINOPYRIDO[2,3-D]PYRIMIDINE COMPOUNDS | ABBOTT LABORATORIES (US) | 2000-04-27 | — | — | WO | disclosed |