Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 1/20 | 0.37 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.37 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.37 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.37 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.31 |
| ▸ | MAPT | P10636 | 2/20 | 0.31 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16985341 | 0.82 | GRIA1 (0.36) | GRIA1GRIA2GRIA3GRIA4TDP1 | |
| SCHEMBL16985359 | 0.77 | CYP4F2 (0.39) | GRIA1GRIA2GRIA3GRIA4LMNA | |
| SCHEMBL23745310 | 0.70 | — | — | |
| SCHEMBL24907460 | 0.70 | — | — | |
| SCHEMBL25019043 | 0.68 | LRRK2 (0.43) | — | |
| SCHEMBL16975556 | 0.65 | ALDH1A1 (0.32) | LMNAALDH1A1 | |
| SCHEMBL25027384 | 0.65 | ALDH1A1 (0.46) | LMNAMAPK1ALDH1A1MAPT | |
| SCHEMBL17785797 | 0.65 | HDAC8 (0.42) | LMNA | |
| SCHEMBL21241142 | 0.64 | ELANE (0.45) | — | |
| SCHEMBL1120130 | 0.64 | LMNA (0.47) | LMNAMAPK1KDM4EALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015113452-A1 | COMPOUNDS | GLAXOSMITHKLINE INTELLECTUAL PROPERTY DEVELOPMENT LIMITED (GB) | 2015-08-06 | — | — | WO | disclosed |