SCHEMBL16986325

SCHEMBL16986325

CN(C(=O)c1c(F)cccc1F)c1cccc(C(=O)N(C(=O)c2cccc(N(C)C(=O)c3c(F)cccc3F)c2F)c2c(Br)cc(C(F)(C(F)(F)F)C(F)(F)F)cc2C(F)(F)F)c1F

nearest known ligand 0.35

Predicted protein targets (top 6)

geneUniProtsupporting neighboursconfidence
RORC P51449 3/20 0.35
GPBAR1 Q8TDU6 6/20 0.34
TLR7 Q9NYK1 1/20 0.33
HDAC8 Q9BY41 1/20 0.31
RORA P35398 1/20 0.30
RORB Q92753 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL16986375 0.89 GPBAR1 (0.36) GPBAR1HDAC8
SCHEMBL16986299 0.88 GPBAR1 (0.35) GPBAR1HDAC8
SCHEMBL27833621 0.85 TLR7 (0.39) RORCGPBAR1TLR7
SCHEMBL1766481 0.84 RORC (0.35) RORCGPBAR1TLR7HDAC8
SCHEMBL16986370 0.84 GPBAR1 (0.34) GPBAR1HDAC8
SCHEMBL12348556 0.82 GPBAR1 (0.38) GPBAR1HDAC8
SCHEMBL28992868 0.82 GPBAR1 (0.36) GPBAR1HDAC8
SCHEMBL1766482 0.81 RORC (0.40) RORCGPBAR1TLR7HDAC8RORA
SCHEMBL1766907 0.80 RORC (0.38) RORCGPBAR1TLR7RORARORB
SCHEMBL1766903 0.80 PTGES (0.34) RORCGPBAR1TLR7

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3392236-B1 METHOD FOR PRODUCING AROMATIC AMIDE DERIVATIVE MITSUI CHEMICALS AGRO INC (JP) 2021-06-23 EP disclosed
US-10647660-B2 Method of producing aromatic amide derivative MITSUI CHEMICALS AGRO, INC. (JP) 2020-05-12 US disclosed
EP-2905274-B1 IMIDE COMPOUND, METHOD FOR MANUFACTURING SAME, AND USE AS INSECTICIDE MITSUI CHEMICALS AGRO INC (JP) 2019-09-25 EP disclosed
US-20180362447-A1 METHOD OF PRODUCING AROMATIC AMIDE DERIVATIVE MITSUI CHEMICALS AGRO, INC. (JP) 2018-12-20 US disclosed
EP-3392236-A1 METHOD FOR PRODUCING AROMATIC AMIDE DERIVATIVE Mitsui Chemicals Agro, Inc. (JP) 2018-10-24 EP disclosed
US-9328062-B2 Imide compound, method for manufacturing same, and use as insecticide MITSUI CHEMICALS AGRO, INC. (JP) 2016-05-03 US disclosed
US-20150246872-A1 IMIDE COMPOUND, METHOD FOR MANUFACTURING SAME, AND USE AS INSECTICIDE MITSUI CHEMICALS AGRO, INC. (JP) 2015-09-03 US disclosed
EP-2905274-A1 IMIDE COMPOUND, METHOD FOR MANUFACTURING SAME, AND USE AS INSECTICIDE Mitsui Chemicals Agro, Inc. (JP) 2015-08-12 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20150246872-A1 IMIDE COMPOUND, METHOD FOR MANUFACTURING SAME, AND USE AS INSECTICIDE CYP2E1, CYP1A1, CYP4B1 RORC 3920/4885GPBAR1 4463/4885TLR7 2299/4885
US-20180362447-A1 METHOD OF PRODUCING AROMATIC AMIDE DERIVATIVE HDHD5, NAAA, H1-4 RORC 4728/4885GPBAR1 4388/4885TLR7 3303/4885
US-10647660-B2 Method of producing aromatic amide derivative HDHD5, NAAA, H1-4 RORC 4728/4885GPBAR1 4388/4885TLR7 3303/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.