Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 1/20 | 0.37 |
| ▸ | ESR2 | Q92731 | 1/20 | 0.37 |
| ▸ | SHBG | P04278 | 1/20 | 0.36 |
| ▸ | CXCR3 | P49682 | 1/20 | 0.34 |
| ▸ | SLC18A3 | Q16572 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.32 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.32 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.32 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.32 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16988319 | 1.00 | ESR1 (0.37) | ESR1ESR2SHBGCXCR3SLC18A3 | |
| SCHEMBL16987905 | 0.87 | SHBG (0.34) | SHBGCXCR3MAPK1CYP3A4ALOX15 | |
| SCHEMBL16988277 | 0.85 | KDM1A (0.36) | SHBGOPRL1OPRM1 | |
| SCHEMBL16988305 | 0.85 | SLC6A4 (0.42) | CXCR3SLC18A3ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL16988291 | 0.83 | ALDH1A1 (0.42) | CXCR3ALDH1A1OPRM1SMN1; SMN2MEN1 | |
| SCHEMBL16988294 | 0.83 | ALDH1A1 (0.42) | CXCR3ALDH1A1OPRM1SMN1; SMN2MEN1 | |
| SCHEMBL16988723 | 0.81 | GAA (0.39) | ALDH1A1OPRL1OPRM1SMN1; SMN2KMT2A | |
| SCHEMBL16988578 | 0.80 | ALDH1A1 (0.41) | ESR1ESR2ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL16988580 | 0.80 | ALDH1A1 (0.41) | ESR1ESR2ALDH1A1MAPK1SMN1; SMN2 | |
| SCHEMBL4232429 | 0.75 | ESR1 (0.42) | ESR1ESR2SHBGMAPK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3097089-B1 | ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS INC (US) | 2021-02-24 | — | — | EP | disclosed |
| US-9464082-B2 | Aryl and arylalkyl substituted pyrazolyl and pyrimidinyl tricyclic enones as antioxidant inflammation modulators | ABBVIE INC. (US) | 2016-10-11 | — | — | US | disclosed |
| US-20150225397-A1 | ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | REATA PHARMACEUTICALS, INC. | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225397-A1 | ARYL AND ARYLALKYL SUBSTITUTED PYRAZOLYL AND PYRIMIDINYL TRICYCLIC ENONES AS ANTIOXIDANT INFLAMMATION MODULATORS | GPX4, TXN2, MPO | ESR1 362/4885ESR2 142/4885SHBG 2642/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.