Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP19A1 | P11511 | 2/20 | 0.42 |
| ▸ | CYP11B1 | P15538 | 2/20 | 0.42 |
| ▸ | CYP11B2 | P19099 | 2/20 | 0.42 |
| ▸ | MAPT | P10636 | 4/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.39 |
| ▸ | MEN1 | O00255 | 4/20 | 0.39 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | CTSB | P07858 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8566712 | 0.79 | CYP19A1 (0.43) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL7116983 | 0.77 | KMT2A (0.50) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL1699180 | 0.77 | LMNA (0.44) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL28992901 | 0.72 | ALDH1A1 (0.40) | MAPTKMT2AMEN1NPC1RAB9A | |
| SCHEMBL8568481 | 0.71 | HTT (0.50) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL4954517 | 0.71 | CYP19A1 (0.41) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL4954513 | 0.70 | MEN1 (0.46) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL1735333 | 0.67 | MAPT (0.50) | CYP19A1CYP11B1CYP11B2MAPTKMT2A | |
| SCHEMBL8568534 | 0.67 | CYP19A1 (0.40) | CYP19A1CYP11B1CYP11B2MAPTNPC1 | |
| SCHEMBL31419067 | 0.65 | ALDH1A1 (0.46) | MAPTKMT2AMEN1LMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2585462-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | Takeda Pharmaceutical Company Limited (JP) | 2013-05-01 | — | — | EP | disclosed |
| WO-2011163355-A1 | FUSED HETEROCYCLIC COMPOUNDS AS PHOSPHODIESTERASES (PDES) INHIBITORS | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2011-12-29 | — | — | WO | disclosed |