Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | PROKR1 | Q8TCW9 | 4/20 | 0.42 |
| ▸ | FPR2 | P25090 | 3/20 | 0.42 |
| ▸ | P2RX7 | Q99572 | 6/20 | 0.39 |
| ▸ | MPO | P05164 | 2/20 | 0.38 |
| ▸ | AURKA | O14965 | 1/20 | 0.35 |
| ▸ | JAK2 | O60674 | 1/20 | 0.35 |
| ▸ | JAK1 | P23458 | 1/20 | 0.35 |
| ▸ | TYK2 | P29597 | 1/20 | 0.35 |
| ▸ | JAK3 | P52333 | 1/20 | 0.35 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.35 |
| ▸ | LIMK2 | P53671 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 1/20 | 0.34 |
| ▸ | TDO2 | P48775 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16992785 | 0.84 | ALDH1A1 (0.40) | ALDH1A1POLBTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL16992820 | 0.81 | SMN1; SMN2 (0.46) | ALDH1A1POLBTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL6218818 | 0.80 | ALDH1A1 (0.44) | ALDH1A1POLBKMT2AHTTP2RX7 | |
| SCHEMBL13516409 | 0.76 | P2RX7 (0.45) | ALDH1A1POLBKMT2ASMN1; SMN2P2RX7 | |
| SCHEMBL13516703 | 0.74 | CCR2 (0.50) | POLBSMN1; SMN2P2RX7MPO | |
| SCHEMBL13516129 | 0.74 | SMN1; SMN2 (0.50) | ALDH1A1KMT2ASMN1; SMN2HTTP2RX7 | |
| SCHEMBL14720127 | 0.71 | PNMT (0.43) | SMN1; SMN2P2RX7IDO1 | |
| SCHEMBL4604208 | 0.71 | KMT2A (0.48) | ALDH1A1POLBTSHRKMT2ASMN1; SMN2 | |
| SCHEMBL14720282 | 0.70 | ALDH1A1 (0.47) | ALDH1A1TSHRKMT2ASMN1; SMN2HTT | |
| SCHEMBL25423598 | 0.67 | PTGER1 (0.39) | ALDH1A1POLBTSHRKMT2AMPO |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2015118434-A1 | PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS KINASE JAK-2 INHIBITORS | CELON PHARMA S.A. (PL) | 2015-08-13 | — | — | WO | disclosed |