Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCR2 | P41597 | 4/20 | 0.50 |
| ▸ | P2RX7 | Q99572 | 1/20 | 0.49 |
| ▸ | MPO | P05164 | 1/20 | 0.44 |
| ▸ | HCAR2 | Q8TDS4 | 1/20 | 0.44 |
| ▸ | ADCY10 | Q96PN6 | 1/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | YTHDF3 | Q7Z739 | 2/20 | 0.42 |
| ▸ | YTHDC1 | Q96MU7 | 2/20 | 0.42 |
| ▸ | YTHDF1 | Q9BYJ9 | 2/20 | 0.42 |
| ▸ | YTHDF2 | Q9Y5A9 | 2/20 | 0.42 |
| ▸ | PNMT | P11086 | 2/20 | 0.42 |
| ▸ | CCR5 | P51681 | 1/20 | 0.42 |
| ▸ | ENPP1 | P22413 | 1/20 | 0.42 |
| ▸ | PDE5A | O76074 | 1/20 | 0.42 |
| ▸ | PDE9A | O76083 | 1/20 | 0.42 |
| ▸ | PDE1A | P54750 | 1/20 | 0.42 |
| ▸ | PDE1B | Q01064 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13516409 | 0.81 | P2RX7 (0.45) | P2RX7MPOPOLBMAPTSMN1; SMN2 | |
| SCHEMBL9353066 | 0.81 | MEN1 (0.46) | POLB | |
| SCHEMBL16992848 | 0.74 | ALDH1A1 (0.47) | P2RX7MPOPOLBSMN1; SMN2 | |
| SCHEMBL14720127 | 0.73 | PNMT (0.43) | CCR2P2RX7SMN1; SMN2PNMTCCR5 | |
| SCHEMBL7397450 | 0.73 | MPO (0.49) | CCR2MPOHCAR2ADCY10YTHDF3 | |
| SCHEMBL13516129 | 0.73 | SMN1; SMN2 (0.50) | P2RX7MPOSMN1; SMN2PNMTENPP1 | |
| SCHEMBL5753192 | 0.71 | PDE5A (0.51) | CCR2P2RX7HCAR2SMN1; SMN2YTHDF3 | |
| SCHEMBL18148766 | 0.71 | MPO (0.47) | MPOHCAR2YTHDF3YTHDC1YTHDF1 | |
| SCHEMBL20744794 | 0.70 | ADORA2A (0.42) | MPOHCAR2POLBYTHDF3YTHDC1 | |
| SCHEMBL857948 | 0.70 | ENPP1 (0.49) | CCR2ADCY10MAPTSMN1; SMN2PNMT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | BIOENERGENIX LLC (US) | 2021-03-23 | — | — | US | disclosed |
| WO-2012149157-A2 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-11-01 | — | — | WO | disclosed |
| US-20120277224-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | BIOENERGENIX (US) | 2012-11-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120277224-A1 | HETEROCYCLIC COMPOUNDS FOR THE INHIBITION OF PASK | PASK, PDXK, PANK2 | CCR2 4033/4885P2RX7 3547/4885MPO 1428/4885 |
| US-10953012-B2 | Heterocyclic compounds for the inhibition of pask | PASK, PDXK, PANK2 | CCR2 4033/4885P2RX7 3547/4885MPO 1428/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.