Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRHR1 | P34998 | 6/20 | 0.43 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | GUSB | P08236 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 3/20 | 0.38 |
| ▸ | TNKS | O95271 | 1/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.37 |
| ▸ | DPP4 | P27487 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | HTT | P42858 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2885158 | 0.78 | CYP1A2 (0.45) | KDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL1699417 | 0.69 | CRHR1 (0.45) | CRHR1KDM4EMAPK1GUSBHSD11B1 | |
| SCHEMBL7943109 | 0.68 | ALDH1A1 (0.40) | KDM4EMAPK1L3MBTL1HTTALDH1A1 | |
| SCHEMBL2172611 | 0.67 | CYP2A6 (0.45) | KDM4EL3MBTL1ALDH1A1HPGD | |
| SCHEMBL10271797 | 0.66 | CRHR1 (0.42) | CRHR1KDM4EMAPK1GUSBHSD11B1 | |
| SCHEMBL11574890 | 0.64 | TRPM4 (0.43) | KDM4EHTTALDH1A1HPGD | |
| SCHEMBL3761176 | 0.64 | CRHR1 (0.53) | CRHR1KDM4EHSD11B1DPP4NPC1 | |
| SCHEMBL28232175 | 0.64 | CYP11B2 (0.55) | CRHR1KDM4EMAPK1GUSBDPP4 | |
| SCHEMBL464507 | 0.63 | AHR (0.64) | CRHR1KDM4EMAPK1HSD11B1HSP90AA1 | |
| SCHEMBL29624840 | 0.63 | AHR (0.64) | CRHR1KDM4EMAPK1HSD11B1HSP90AA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2588450-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | Gilead Sciences, Inc. (US) | 2013-05-08 | — | — | EP | disclosed |
| WO-2012003497-A1 | NAPHT- 2 -YLACETIC ACID DERIVATIVES TO TREAT AIDS | GILEAD SCIENCES, INC. (US) | 2012-01-05 | — | — | WO | disclosed |