Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HINT1 | P49773 | 4/20 | 0.50 |
| ▸ | STING1 | Q86WV6 | 4/20 | 0.47 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.47 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.47 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.47 |
| ▸ | TAAR1 | Q96RJ0 | 1/20 | 0.47 |
| ▸ | NT5E | P21589 | 1/20 | 0.46 |
| ▸ | PNP | P00491 | 1/20 | 0.46 |
| ▸ | GSK3A | P49840 | 2/20 | 0.44 |
| ▸ | RPS6KA3 | P51812 | 2/20 | 0.44 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.44 |
| ▸ | TGM2 | P21980 | 1/20 | 0.43 |
| ▸ | KRAS | P01116 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16998078 | 0.85 | ADORA3 (0.54) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16998240 | 0.85 | ADORA3 (0.54) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16991551 | 0.85 | ADORA3 (0.54) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16991643 | 0.85 | ADORA3 (0.54) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16998156 | 0.84 | ADORA3 (0.52) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL12851722 | 0.83 | ADORA3 (0.53) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL26269047 | 0.82 | HINT1 (0.51) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL26269037 | 0.82 | HINT1 (0.51) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16997790 | 0.81 | ADORA3 (0.51) | HINT1STING1PDE3BPDE3AADORA3 | |
| SCHEMBL16997922 | 0.81 | ADORA3 (0.51) | HINT1STING1PDE3BPDE3AADORA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2017-10-19 | — | — | US | disclosed |
| US-9370569-B2 | 4′-difluoromethyl substituted nucleoside derivatives as inhibitors of influenza RNA replication | RIBOSCIENCE LLC (US) | 2016-06-21 | — | — | US | disclosed |
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RIBOSCIENCE LLC | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225441-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | HINT1 125/4885STING1 196/4885PDE3B 789/4885 |
| US-20170296664-A1 | 4'-Difluoromethyl Substituted Nucleoside Derivatives as Inhibitors of Influenza RNA Replication | RNMT, DUT, RNGTT | HINT1 125/4885STING1 196/4885PDE3B 789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.