Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NPC1 | O15118 | 6/20 | 0.73 |
| ▸ | RAB9A | P51151 | 5/20 | 0.73 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.73 |
| ▸ | MEN1 | O00255 | 2/20 | 0.73 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.73 |
| ▸ | POLB | P06746 | 1/20 | 0.73 |
| ▸ | MAOB | P27338 | 1/20 | 0.73 |
| ▸ | TP53 | P04637 | 1/20 | 0.73 |
| ▸ | HPGD | P15428 | 1/20 | 0.73 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 3/20 | 0.66 |
| ▸ | CA1 | P00915 | 2/20 | 0.66 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.64 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | CA12 | O43570 | 1/20 | 0.61 |
| ▸ | CA9 | Q16790 | 1/20 | 0.61 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.61 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.61 |
| ▸ | RORC | P51449 | 1/20 | 0.61 |
| ▸ | NAMPT | P43490 | 2/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2831462 | 0.93 | NPC1 (0.77) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL14025738 | 0.90 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL11618171 | 0.88 | HTT (0.81) | HTTROCK2ROCK1NAMPT | |
| SCHEMBL4744610 | 0.86 | NPC1 (0.69) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL4743393 | 0.86 | NPC1 (0.73) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL7420189 | 0.85 | RAB9A (1.00) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL13720058 | 0.85 | NPC1 (1.00) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL27953145 | 0.85 | RAB9A (0.72) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL27942151 | 0.85 | NPC1 (0.71) | NPC1RAB9ASMN1; SMN2MEN1KMT2A | |
| SCHEMBL2704691 | 0.84 | MAPT (0.66) | NPC1RAB9ASMN1; SMN2MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | MERCK PATENT GMBH (DE) | 2015-08-13 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150225369-A1 | DDR2 INHIBITORS FOR THE TREATMENT OF OSTEOARTHRITIS | DDR2, DDR1, DDRGK1 | NPC1 4492/4885RAB9A 3723/4885SMN1; SMN2 1789/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.