Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5 | P09917 | 1/20 | 0.56 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.54 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.52 |
| ▸ | POLB | P06746 | 1/20 | 0.51 |
| ▸ | PLAAT3 | P53816 | 1/20 | 0.50 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.50 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.50 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.50 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.50 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.50 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17009151 | 0.85 | PLAAT3 (0.44) | ALOX5POLBPLAAT3PLAAT5PLAAT2 | |
| SCHEMBL17009104 | 0.82 | PPARA (0.53) | ALOX5CYP1A2CYP3A4KMT2A | |
| SCHEMBL10697795 | 0.81 | HTT (0.57) | F2RL1ALDH1A1POLBCYP3A4CYP2C19 | |
| SCHEMBL5271327 | 0.80 | FAAH (0.60) | ALOX5F2RL1ALDH1A1POLBRAB9A | |
| SCHEMBL1274985 | 0.78 | ALOX5 (0.66) | ALOX5F2RL1ALDH1A1POLBPLAAT3 | |
| SCHEMBL19520266 | 0.77 | F2RL1 (0.58) | ALOX5F2RL1ALDH1A1POLBCYP1A2 | |
| SCHEMBL10508508 | 0.76 | ALOX5 (0.49) | ALOX5F2RL1ALDH1A1POLBPLAAT3 | |
| SCHEMBL1105476 | 0.76 | ALOX5 (0.68) | ALOX5F2RL1ALDH1A1POLBPLAAT3 | |
| SCHEMBL503646 | 0.76 | ALOX5 (0.68) | ALOX5F2RL1ALDH1A1PLAAT3PLAAT5 | |
| SCHEMBL659052 | 0.76 | ALOX5 (0.68) | ALOX5F2RL1ALDH1A1POLBPLAAT3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-106029640-B | Pyrazolinone compounds and application thereof | 泰普斯特医疗公司 | 2018-08-24 | — | — | CN | disclosed |
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION SCIENCES, INC. | 2018-03-22 | — | — | US | disclosed |
| US-9862708-B2 | Pyrazolone compounds and uses thereof | TEMPEST THERAPEUTICS, INC. (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2017-06-22 | — | — | US | disclosed |
| EP-3105205-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | Inception 2, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123133-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION 2, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | ALOX5 107/4885F2RL1 1036/4885ALDH1A1 490/4885 |
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | ALOX5 153/4885F2RL1 779/4885ALDH1A1 542/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.