Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLAAT3 | P53816 | 1/20 | 0.44 |
| ▸ | PLAAT5 | Q96KN8 | 1/20 | 0.44 |
| ▸ | PLAAT2 | Q9NWW9 | 1/20 | 0.44 |
| ▸ | PLAAT4 | Q9UL19 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | CTDSP1 | Q9GZU7 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 2/20 | 0.40 |
| ▸ | IDO1 | P14902 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | FPR2 | P25090 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.39 |
| ▸ | FAAH | O00519 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.39 |
| ▸ | CYP4A11 | Q02928 | 2/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | GLA | P06280 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17009142 | 0.85 | ALOX5 (0.56) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1858237 | 0.78 | IDO1 (0.55) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL17009104 | 0.77 | PPARA (0.53) | KMT2AALOX5GLA | |
| SCHEMBL17451869 | 0.75 | POLB (0.44) | POLBCTDSP1LMNAIDO1KMT2A | |
| SCHEMBL28290264 | 0.75 | HDAC1 (0.45) | PLAAT3PLAAT5PLAAT2PLAAT4LMNA | |
| SCHEMBL2146699 | 0.74 | TDP1 (0.47) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL17009102 | 0.74 | IDO1 (0.48) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL17593254 | 0.73 | IDO1 (0.53) | IDO1KMT2AHDAC1CYP4A11TDP1 | |
| SCHEMBL3907853 | 0.72 | PLAAT3 (0.50) | PLAAT3PLAAT5PLAAT2PLAAT4POLB | |
| SCHEMBL1377057 | 0.71 | PLAAT3 (0.53) | PLAAT3PLAAT5PLAAT2PLAAT4POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION SCIENCES, INC. | 2018-03-22 | — | — | US | disclosed |
| US-9862708-B2 | Pyrazolone compounds and uses thereof | TEMPEST THERAPEUTICS, INC. (US) | 2018-01-09 | — | — | US | disclosed |
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | TEMPEST THERAPEUTICS, INC. | 2017-06-22 | — | — | US | disclosed |
| EP-3105205-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | Inception 2, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123133-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | INCEPTION 2, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170174666-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | PLAAT3 157/4885PLAAT5 265/4885PLAAT2 458/4885 |
| US-20180079745-A1 | PYRAZOLONE COMPOUNDS AND USES THEREOF | PPARA, PPARG, PPARD | PLAAT3 298/4885PLAAT5 539/4885PLAAT2 820/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.