Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 9/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.46 |
| ▸ | HPGD | P15428 | 5/20 | 0.46 |
| ▸ | MAPT | P10636 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.44 |
| ▸ | MPO | P05164 | 1/20 | 0.42 |
| ▸ | XDH | P47989 | 1/20 | 0.42 |
| ▸ | AR | P10275 | 1/20 | 0.40 |
| ▸ | GAA | P10253 | 2/20 | 0.40 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | GRIN2D | O15399 | 1/20 | 0.40 |
| ▸ | GRIN3B | O60391 | 1/20 | 0.40 |
| ▸ | GRIN1 | Q05586 | 1/20 | 0.40 |
| ▸ | GRIN2A | Q12879 | 1/20 | 0.40 |
| ▸ | GRIN2B | Q13224 | 1/20 | 0.40 |
| ▸ | GRIN2C | Q14957 | 1/20 | 0.40 |
| ▸ | GRIN3A | Q8TCU5 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12806740 | 0.94 | MEN1 (0.43) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL17009602 | 0.84 | PARP10 (0.49) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL31105544 | 0.82 | KDM4E (0.50) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL31664560 | 0.80 | KDM4E (0.59) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL13429082 | 0.78 | CYP1A2 (0.47) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL31060830 | 0.77 | EGFR (0.52) | KDM4EALDH1A1HPGDMAPTSMN1; SMN2 | |
| SCHEMBL1771739 | 0.76 | AR (0.56) | KDM4EALDH1A1MAPTARGAA | |
| SCHEMBL13429118 | 0.75 | HPGD (0.45) | KDM4EALDH1A1HPGDSMN1; SMN2XDH | |
| SCHEMBL3227054 | 0.74 | AR (0.49) | HPGDSMN1; SMN2XDHARMEN1 | |
| SCHEMBL13429012 | 0.73 | XDH (0.44) | HPGDSMN1; SMN2XDHARMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11504363-B2 | Method of treating cancer and bone cancer pain | EXELIXIS, INC. (US) | 2022-11-22 | — | — | US | disclosed |
| EP-3105204-A1 | CRYSTALLINE SOLID FORMS OF N-{4-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]PHENYL}-N'-(4-FLUOROPHENYL) CYCLOPROPANE-1, 1-DICARBOXAMIDE, PROCESSES FOR MAKING, AND METHODS OF USE | Exelixis, Inc. (US) | 2016-12-21 | — | — | EP | disclosed |
| WO-2015123639-A1 | CRYSTALLINE SOLID FORMS OF N-{4-[(6,7-DIMETHOXYQUINOLIN-4-YL)OXY]PHENYL}-N'-(4-FLUOROPHENYL) CYCLOPROPANE-1, 1-DICARBOXAMIDE, PROCESSES FOR MAKING, AND METHODS OF USE | EXELIXIS, INC. (US) | 2015-08-20 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-11504363-B2 | Method of treating cancer and bone cancer pain | TPO, OGFR, CALCR | KDM4E 3505/4885ALDH1A1 723/4885HPGD 1696/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.