Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 2/20 | 0.46 |
| ▸ | CKS1B | P61024 | 1/20 | 0.46 |
| ▸ | SKP1 | P63208 | 1/20 | 0.46 |
| ▸ | SKP2 | Q13309 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 2/20 | 0.43 |
| ▸ | F10 | P00742 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | GPR119 | Q8TDV5 | 4/20 | 0.42 |
| ▸ | TPSAB1 | Q15661 | 2/20 | 0.41 |
| ▸ | CTSB | P07858 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8208875 | 0.85 | LMNA (0.48) | LMNASMN1; SMN2HPGDPOLBCKS1B | |
| SCHEMBL8208262 | 0.76 | CHRM4 (0.47) | LMNASMN1; SMN2HPGDPOLBCKS1B | |
| SCHEMBL5776667 | 0.69 | GPR119 (0.51) | F10GPR119CTSBCTSSCTSK | |
| SCHEMBL8201048 | 0.69 | USP30 (0.47) | LMNASMN1; SMN2HPGDPOLBALDH1A1 | |
| SCHEMBL8212238 | 0.69 | F10 (0.49) | HSD11B1F10 | |
| SCHEMBL8208874 | 0.67 | PDGFRB (0.43) | LMNASMN1; SMN2HPGDPOLBCKS1B | |
| SCHEMBL24151174 | 0.67 | P2RX7 (0.51) | — | |
| SCHEMBL27712450 | 0.65 | GPR119 (0.50) | LMNASMN1; SMN2HPGDCKS1BSKP1 | |
| SCHEMBL13465197 | 0.65 | CNR1 (0.52) | LMNACKS1BSKP1SKP2MEN1 | |
| SCHEMBL12469013 | 0.65 | PRKCQ (0.53) | CKS1BSKP1SKP2HSD11B1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2132178-B1 | JNK INHIBITORS | MERCK SHARP & DOHME (US) | 2015-08-19 | — | — | EP | disclosed |
| US-8975389-B2 | Nucleic acid chemical modifications | ALNYLAM PHARMACEUTICALS, INC. (US) | 2015-03-10 | — | — | US | disclosed |