Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ELANE | P08246 | 12/20 | 0.38 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.37 |
| ▸ | MCOLN3 | Q8TDD5 | 1/20 | 0.37 |
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.35 |
| ▸ | TRPV4 | Q9HBA0 | 1/20 | 0.34 |
| ▸ | DRD2 | P14416 | 1/20 | 0.34 |
| ▸ | DRD3 | P35462 | 1/20 | 0.34 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.34 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL123911 | 0.84 | ELANE (0.40) | ELANETRPV4SLC6A4 | |
| SCHEMBL172209 | 0.81 | HTR6 (0.41) | HCRTR2MCOLN3POLBSCN9A | |
| SCHEMBL124314 | 0.71 | ELANE (0.42) | ELANEEPAS1 | |
| SCHEMBL172154 | 0.70 | HCRTR2 (0.36) | HCRTR2POLB | |
| SCHEMBL4697009 | 0.69 | DRD2 (0.50) | POLBDRD2DRD3 | |
| SCHEMBL171759 | 0.68 | MAOA (0.41) | HCRTR2POLBDRD2DRD3SCN9A | |
| SCHEMBL9906430 | 0.68 | KCNH2 (0.46) | — | |
| SCHEMBL15932447 | 0.68 | TRPV4 (0.45) | ELANETRPV4 | |
| SCHEMBL123160 | 0.68 | GRIA4 (0.35) | ELANEMCOLN3POLB | |
| SCHEMBL20997500 | 0.67 | TRPV4 (0.44) | POLBTRPV4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2234985-B1 | 4-(4-CYANO-2-THIOARYL)DIHYDROPYRIMIDINONES AND USE THEREOF | Bayer Pharma AG (DE) | 2012-03-07 | — | — | EP | disclosed |