Known targets — ChEMBL curated mechanism
ADRB1ADRB2ATP4AATP4BAXLCHRM2CHRM3DRD2FLT3HRH1HTR2AHTR2BHTR2CKCNH2KMT2AMAP2K1MAP2K2MEN1MLNRPLK4RENS1PR1SLC6A2SLC6A4atpAatpBatpCatpDatpEatpFatpFHatpGpol
The experimentally established mechanism targets of Fumaric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 known ✓ | O00255 | 3/20 | 0.49 |
| ▸ | KMT2A known ✓ | Q03164 | 3/20 | 0.49 |
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 0.82 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 0.82 |
| ▸ | SMN1; SMN2 | Q16637 | 6/20 | 0.82 |
| ▸ | MAPT | P10636 | 3/20 | 0.82 |
| ▸ | LMNA | P02545 | 3/20 | 0.82 |
| ▸ | MITF | O75030 | 1/20 | 0.82 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 2/20 | 0.49 |
| ▸ | HTT | P42858 | 2/20 | 0.49 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.46 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fumaric Acid SCHEMBL13277769 | 1.00 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Fumaric Acid SCHEMBL13277766 | 1.00 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Fumaric Acid SCHEMBL13277768 | 1.00 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL1701097 | 0.91 | TRPM8 (1.00) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| SCHEMBL29968698 | 0.91 | TRPM8 (1.00) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Cadaverine Tartrate SCHEMBL1701294 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Succinic Acid SCHEMBL13277748 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Succinic Acid SCHEMBL1701275 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Cadaverine Tartrate SCHEMBL13277601 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA | |
| Malic Acid SCHEMBL13278134 | 0.86 | TRPM8 (0.72) | TRPM8L3MBTL1SMN1; SMN2MAPTLMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 13 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3663366-B1 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2025-01-08 | — | — | EP | disclosed |
| CN-111053775-B | Physiologically cool active ingredient and use of substances containing such active ingredient | 西姆莱斯股份公司 | 2023-08-18 | — | — | CN | disclosed |
| CN-111053775-A | Physiologically cooling active ingredients and use of substances containing such active ingredients | 西姆莱斯股份公司 | 2020-04-24 | — | — | CN | disclosed |
| US-10584134-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2020-03-10 | — | — | US | disclosed |
| CN-102844386-B | Physiologically cooling active ingredients and use of substances containing such active ingredients | 西姆莱斯股份公司 | 2020-01-21 | — | — | CN | disclosed |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2018-04-05 | — | — | US | disclosed |
| US-9718839-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2017-08-01 | — | — | US | disclosed |
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2015-03-26 | — | — | US | disclosed |
| US-8927605-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | SYMRISE AG (DE) | 2015-01-06 | — | — | US | disclosed |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | BASF SE (DE) | 2012-10-18 | — | — | US | disclosed |
| EP-2501761-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | Symrise AG (DE) | 2012-09-26 | — | — | EP | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150086491-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | MEN1 655/4885KMT2A 3280/4885TRPM8 1/4885 |
| US-10584134-B2 | Use of physiological cooling active ingredients, and agents containing such active ingredients | TRPM8, TRPM7, TRPM2 | MEN1 655/4885KMT2A 3280/4885TRPM8 1/4885 |
| US-20180093997-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | MEN1 655/4885KMT2A 3280/4885TRPM8 1/4885 |
| US-20120263659-A1 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | TRPM8, TRPM7, TRPM2 | MEN1 655/4885KMT2A 3280/4885TRPM8 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.