Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM8 | Q7Z2W7 | 11/20 | 1.00 |
| ▸ | L3MBTL1 | Q9Y468 | 8/20 | 1.00 |
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 1.00 |
| ▸ | LMNA | P02545 | 5/20 | 1.00 |
| ▸ | MAPT | P10636 | 3/20 | 1.00 |
| ▸ | MITF | O75030 | 1/20 | 1.00 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.58 |
| ▸ | HTT | P42858 | 2/20 | 0.58 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | PPP1CA | P62136 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29968698 | 1.00 | TRPM8 (1.00) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Fumaric Acid SCHEMBL1701484 | 0.91 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Fumaric Acid SCHEMBL13277766 | 0.91 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Fumaric Acid SCHEMBL13277769 | 0.91 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Fumaric Acid SCHEMBL13277768 | 0.91 | TRPM8 (0.82) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Succinic Acid SCHEMBL13277748 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Succinic Acid SCHEMBL1701275 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Cadaverine Tartrate SCHEMBL1701294 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| Cadaverine Tartrate SCHEMBL13277601 | 0.90 | TRPM8 (0.80) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT | |
| SCHEMBL1699152 | 0.90 | TRPM8 (1.00) | TRPM8L3MBTL1SMN1; SMN2LMNAMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 128 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | SENOMYX, INC. (US) | 2019-08-27 | — | — | US | claimed |
| EP-4725476-A2 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | Firmenich SA (CH) | 2026-04-15 | — | — | EP | disclosed |
| EP-4096714-B1 | COMPOSITIONS FOR REDUCING SALTY TASTE AND USES THEREOF | FIRMENICH & CIE (CH) | 2026-01-28 | — | — | EP | disclosed |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-12-25 | — | — | US | disclosed |
| EP-4608518-A1 | ORAL CARE COMPOSITIONS | Firmenich SA (CH) | 2025-09-03 | — | — | EP | disclosed |
| EP-4251122-B1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | FIRMENICH INCORPORATED (US) | 2025-03-12 | — | — | EP | disclosed |
| US-20250064063-A1 | ANTIMICROBIAL COMPOSITION HAVING ENCAPSULATED COLORANT | FIRMENICH SA (CH) | 2025-02-27 | — | — | US | disclosed |
| EP-3663366-B1 | USE OF PHYSIOLOGICAL COOLING INGREDIENTS AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2025-01-08 | — | — | EP | disclosed |
| US-20240307279-A1 | FAST DRYING PERFUME COMPOSITION | FIRMENICH SA (CH) | 2024-09-19 | — | — | US | disclosed |
| US-20240285512-A1 | ORAL CARE COMPOSITIONS | FIRMENICH SA (CH) | 2024-08-29 | — | — | US | disclosed |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | VIFOR (INTERNATIONAL) AG (CH) | 2012-08-09 | — | — | US | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| WO-2011061330-A9 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2012-01-05 | — | — | WO | disclosed |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2011-06-23 | — | — | US | disclosed |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2011-06-23 | — | — | US | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
| WO-2011061330-A2 | USE OF PHYSIOLOGICAL COOLING ACTIVE INGREDIENTS, AND AGENTS CONTAINING SUCH ACTIVE INGREDIENTS | SYMRISE AG (DE) | 2011-05-26 | — | — | WO | disclosed |
| WO-2011026835-A1 | NOVEL PYRIMIDINE AND TRIAZINE HEPCIDINE ANTAGONISTS | VIFOR (INTERNATIONAL) AG (CH) | 2011-03-10 | — | — | WO | disclosed |
| WO-2010149798-A2 | USE OF POLYOLS FOR ENHANCING THE COOLING EFFECT OF A COOLING SUBSTANCE AND COOLING MIXTURES HAVING AN ENHANCED COOLING EFFECT | SYMRISE AG (DE) | 2010-12-29 | — | — | WO | disclosed |
| WO-2010026094-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | BASF SE (DE) | 2010-03-11 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10392371-B2 | Compounds useful as modulators of TRPM8 | TRPM8, TRPM4, TRPM6 | TRPM8 1/4885L3MBTL1 3284/4885SMN1; SMN2 2480/4885 |
| US-20120202806-A1 | Novel Pyrimidine- And Triazine-Hepcidine Antagonists | HAMP, DHPS, SLC40A1 | TRPM8 2345/4885L3MBTL1 3829/4885SMN1; SMN2 4562/4885 |
| US-20250387310-A1 | COMPOSITIONS THAT ENHANCE THE COOLING EFFECT | TAS2R30, TAS2R1, TAS2R20 | TRPM8 165/4885L3MBTL1 3320/4885SMN1; SMN2 651/4885 |
| US-20110145970-A1 | DETECTION AND USE OF LOW MOLECULAR-WEIGHT MODULATORS OF THE COLD-MENTHOL RECEPTOR TRPM8 | TRPM8, TRPM2, TRPM7 | TRPM8 1/4885L3MBTL1 3676/4885SMN1; SMN2 4627/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.