SCHEMBL170181

SCHEMBL170181

Oc1cnc2ccc3cccnc3c2c1

nearest known ligand 0.61

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LMNA P02545 3/20 0.61
KDM4E B2RXH2 5/20 0.48
SMN1; SMN2 Q16637 4/20 0.48
TDP1 Q9NUW8 4/20 0.48
MAPT P10636 4/20 0.48
CCR1 P32246 3/20 0.48
CCR5 P51681 3/20 0.48
CCR8 P51685 3/20 0.48
HTT P42858 3/20 0.48
HSP90AA1 P07900 3/20 0.48
MMP2 P08253 2/20 0.48
TSHR P16473 2/20 0.48
CYP3A4 P08684 2/20 0.48
TP53 P04637 2/20 0.48
NFKB1 P19838 2/20 0.48
GMNN O75496 1/20 0.48
CYP2D6 P10635 1/20 0.48
MMP9 P14780 1/20 0.48
ALOX15 P16050 1/20 0.48
MMP8 P22894 1/20 0.48

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18774829 0.80 CCR1 (0.65) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL12853125 0.80 LMNA (0.61) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL12853122 0.80 LMNA (0.61) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL170352 0.80 LMNA (0.61) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL7555958 0.80 LMNA (0.56) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL28822835 0.80 LMNA (0.56) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL16541136 0.79 CDK5 (0.41) LMNAKDM4EMAPTHTTHSP90AA1
SCHEMBL29871258 0.79 ALDH1A1 (0.58) LMNAKDM4ESMN1; SMN2TDP1MAPT
Phenanthroline SCHEMBL10380787 0.79 CCR1 (0.62) LMNAKDM4ESMN1; SMN2TDP1MAPT
SCHEMBL21390912 0.79 ALDH1A1 (0.58) LMNAKDM4ESMN1; SMN2TDP1MAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 88 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-118307514-A Organic electroluminescent compound and organic electroluminescent device comprising the same 罗门哈斯电子材料韩国有限公司 2024-07-09 CN disclosed
WO-2024120442-A1 PAK4 PROTEIN DEGRADERS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS CONVERGEN (SUZHOU) PHARMACEUTICAL CO., LTD. (CN) 2024-06-13 WO disclosed
WO-2024114814-A1 JAK INHIBITORS, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS ONQUALITY PHARMACEUTICALS CHINA LTD (CN) 2024-06-06 WO disclosed
WO-2024104384-A1 INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS NUCMITO PHARMACEUTICALS CO. LTD. (CN) 2024-05-23 WO disclosed
WO-2024094064-A1 PYRIMIDINYLAMINOBENZENES FOR TREATING LUNG CANCER WITH DISTANT METASTASIS SUZHOU PUHE BIOPHARMA CO., LTD (CN) 2024-05-10 WO disclosed
WO-2024094125-A1 LIPID COMPOUNDS, LIPID NANOPARTICLES, AND PHARMACEUTICAL COMPOSITIONS Shanghai Circode Biomed Co., Ltd. (CN) 2024-05-10 WO disclosed
WO-2024061157-A1 CARBOHYDRATE-OLIGONUCLEOTIDE CONJUGATES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS KYLONOVA (XIAMEN) BIOPHARMA CO., LTD. (CN) 2024-03-28 WO disclosed
EP-4337628-A1 INDENE COMPOUNDS, PHARMACEUTICAL COMPOSITIONS THEREOF, AND THEIR THERAPEUTIC APPLICATIONS Nucmito Pharmaceuticals Company Limited (CN) 2024-03-20 EP disclosed
EP-4330256-A1 PYRIMIDINYLAMINOBENZENES FOR LUNG CANCER TREATMENT Suzhou Puhe Biopharma Co., Ltd. (CN) 2024-03-06 EP disclosed
WO-2024037503-A1 ANTIBODY-DRUG CONJUGATES, PHARMACEUTICAL COMPOSITIONS, AND THERAPEUTIC APPLICATIONS SHANGHAI RUOTUO BIOSCIENCES CO., LTD. (CN) 2024-02-22 WO disclosed
EP-1555018-A1 REMEDIES FOR NEURODEGENERATIVE DISEASES Institute of Medicinal Molecular Design, Inc. (JP) 2005-07-20 EP disclosed
EP-1535610-A1 THERAPEUTIC AGENT FOR CANCER Institute of Medicinal Molecular Design, Inc. (JP) 2005-06-01 EP disclosed
EP-1535609-A1 NF-KB ACTIVATION INHIBITORS Institute of Medicinal Molecular Design, Inc. (JP) 2005-06-01 EP disclosed
EP-1514544-A1 ANTIALLERGIC Institute of Medicinal Molecular Design, Inc. (JP) 2005-03-16 EP disclosed
EP-1512397-A1 O-SUBSTITUTED HYDROXYARYL DERIVATIVES Institute of Medicinal Molecular Design, Inc. (JP) 2005-03-09 EP disclosed
EP-1512396-A1 INHIBITORS AGAINST THE ACTIVATION OF AP-1 AND NFAT Institute of Medicinal Molecular Design, Inc. (JP) 2005-03-09 EP disclosed
EP-1510207-A1 THERAPEUTIC DRUG FOR DIABETES Institute of Medicinal Molecular Design, Inc. (JP) 2005-03-02 EP disclosed
EP-1510210-A1 IMMUNITY-RELATED PROTEIN KINASE INHIBITORS Institute of Medicinal Molecular Design, Inc. (JP) 2005-03-02 EP disclosed
US-20040259877-A1 Inhibitors against the production and release of inflammatory cytokines INSTITUTE OF MEDICINAL MOLECULAR DESIGN, INC. (JP) 2004-12-23 US disclosed
EP-1352650-A1 INHIBITORS AGAINST THE PRODUCTION AND RELEASE OF INFLAMMATORY CYTOKINES Institute of Medicinal Molecular Design, Inc. (JP) 2003-10-15 EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20040259877-A1 Inhibitors against the production and release of inflammatory cytokines NFKBIA, IL1B, IKBKB LMNA 2842/4885KDM4E 3631/4885SMN1; SMN2 4820/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.