Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 4/20 | 0.52 |
| ▸ | KDR | P35968 | 4/20 | 0.44 |
| ▸ | FAAH | O00519 | 9/20 | 0.42 |
| ▸ | LCK | P06239 | 1/20 | 0.41 |
| ▸ | SRC | P12931 | 1/20 | 0.41 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | BCHE | P06276 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.39 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1126140 | 0.85 | HRH3 (0.53) | HRH3KDRKEAP1NFE2L2 | |
| SCHEMBL17023135 | 0.84 | FAAH (0.53) | HRH3FAAH | |
| SCHEMBL17023093 | 0.83 | FGFR3 (0.55) | HRH3KDR | |
| SCHEMBL17023109 | 0.80 | HRH3 (0.41) | HRH3FAAHHSP90AA1BCHE | |
| SCHEMBL17023106 | 0.80 | HRH3 (0.47) | HRH3KDRLCKSRCMAPK14 | |
| SCHEMBL17023029 | 0.75 | FGFR3 (0.50) | — | |
| SCHEMBL17023184 | 0.74 | HSP90AA1 (0.38) | HSP90AA1 | |
| SCHEMBL3352671 | 0.71 | FGFR3 (0.44) | HRH3KDR | |
| SCHEMBL17023015 | 0.71 | L3MBTL1 (0.54) | HSP90AA1 | |
| SCHEMBL12678226 | 0.70 | FGFR3 (0.72) | KDR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2282995-B1 | DERIVATIVES OF QUINOLINES AND QUINOXALINES AS PROTEIN TYROSINE KINASE INHIBITORS | NOVARTIS AG (CH) | 2015-08-26 | — | — | EP | claimed |