Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MDM2 | Q00987 | 1/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.48 |
| ▸ | TAAR1 | Q96RJ0 | 2/20 | 0.47 |
| ▸ | CTSD | P07339 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | TYK2 | P29597 | 1/20 | 0.44 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | PRKCI | P41743 | 2/20 | 0.43 |
| ▸ | BCHE | P06276 | 1/20 | 0.42 |
| ▸ | RAD52 | P43351 | 1/20 | 0.41 |
| ▸ | NT5E | P21589 | 1/20 | 0.41 |
| ▸ | EPHX1 | P07099 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.41 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.40 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11099750 | 0.98 | MDM2 (0.52) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL2949827 | 0.83 | MDM2 (0.47) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL27589604 | 0.82 | TSHR (0.60) | KMT2AMEN1POLBMAPT | |
| SCHEMBL1996992 | 0.82 | F2 (0.50) | GAAMAPT | |
| Hydrochloric Acid SCHEMBL6158030 | 0.81 | TSHR (0.58) | KMT2AMEN1POLBMAPT | |
| SCHEMBL526209 | 0.76 | ALDH1A1 (0.60) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL1703485 | 0.76 | MDM2 (0.54) | MDM2KDM4EL3MBTL1TAAR1CTSD | |
| SCHEMBL230957 | 0.76 | MDM2 (0.67) | MDM2KDM4EL3MBTL1TAAR1KMT2A | |
| SCHEMBL5453827 | 0.76 | BCHE (0.51) | MDM2KDM4EL3MBTL1TAAR1BCHE | |
| SCHEMBL399197 | 0.75 | KIF11 (0.48) | L3MBTL1TAAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 58 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1838696-B1 | NOVEL CYANOGUANIDINE COMPOUNDS | LEO PHARMA AS (DK) | 2016-03-09 | — | — | EP | claimed |
| CN-103073486-A | Polymorphs of N-(6-(4-chlorophenyloxy)hexyl)-N'-cyano-N\"-(4-pyridyl)guanidine, and preparation methods and applications thereof | TIANJIN HEMEI BIOLOG TECHNOLOGY CO LTD | 2013-05-01 | — | — | CN | claimed |
| EP-1838696-A1 | NOVEL CYANOGUANIDINE COMPOUNDS | Leo Pharma A/S (DK) | 2007-10-03 | — | — | EP | claimed |
| WO-2006066584-A1 | NOVEL CYANOGUANIDINE COMPOUNDS | LEO PHARMA A/S (DK) | 2006-06-29 | — | — | WO | claimed |
| EP-1397355-A1 | PYRIDYL CYANOGUANIDINE COMPOUNDS | Leo Pharma A/S (DK) | 2004-03-17 | — | — | EP | claimed |
| CN-1121389-C | Cyanoguanidine as cell proliferation inhibitor | LEO PHARM PROD LTD (DK) | 2003-09-17 | — | — | CN | claimed |
| WO-2002094813-A1 | NOVEL PYRIDYL CYANOGUANIDINE COMPOUNDS | LEO PHARMA A/S (DK) | 2002-11-28 | — | — | WO | claimed |
| CN-1314890-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2001-09-26 | — | — | CN | claimed |
| US-5292886-A | Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate | ESTEVE QUIMICA, S.A., A CORP. OF SPAIN (ES) | 1994-03-08 | — | — | US | claimed |
| EP-0484265-A1 | A process for the preparation of omeprazol | CENTRO GENESIS PARA LA INVESTIGACION, S.L. (ES) | 1992-05-06 | — | — | EP | claimed |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | VALO HEALTH, INC. (US) | 2025-06-24 | — | — | US | disclosed |
| US-12091385-B2 | Pyridinylcyanoguanidine derivative and use thereof | WANG, Zheming (CN) | 2024-09-17 | — | — | US | disclosed |
| US-20240067607-A1 | Pyridinylcyanoguanidine Derivative and Use Thereof | WANG, ZHEMING (CN) | 2024-02-29 | — | — | US | disclosed |
| CN-116283953-B | Indoline compound containing thiazole structure, and preparation method and application thereof | 沈阳药科大学 | 2024-02-02 | — | — | CN | disclosed |
| US-11873284-B2 | Pyridinylcyanoguanidine derivative and use thereof | WANG, Zheming (CN) | 2024-01-16 | — | — | US | disclosed |
| CN-1258279-A | Cyanoguanidines as cell proliferation inhibitors | LEO PHARM PROD LTD (DK) | 2000-06-28 | — | — | CN | disclosed |
| US-5292886-A | Process for the preparation of 2-halomethyl-3,5-dimethyl-4-methoxypyridine halohydrate | ESTEVE QUIMICA, S.A., A CORP. OF SPAIN (ES) | 1994-03-08 | — | — | US | disclosed |
| EP-0484265-A1 | A process for the preparation of omeprazol | CENTRO GENESIS PARA LA INVESTIGACION, S.L. (ES) | 1992-05-06 | — | — | EP | disclosed |
| EP-0061340-A1 | New pharmaceutical compositions containing guanidinopyrimidines | SMITHKLINE BECKMAN CORPORATION (US) | 1982-09-29 | — | — | EP | disclosed |
| US-4336255-A | DIURETICS | SMITHKLINE CORPORATION (US) | 1982-06-22 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240067607-A1 | Pyridinylcyanoguanidine Derivative and Use Thereof | NAMPT, NAPRT, NNMT | MDM2 3869/4885KDM4E 1661/4885L3MBTL1 2804/4885 |
| US-11873284-B2 | Pyridinylcyanoguanidine derivative and use thereof | NAMPT, NAPRT, NNT | MDM2 3733/4885KDM4E 1773/4885L3MBTL1 2971/4885 |
| US-12336981-B2 | Compounds and compositions for the inhibition of NAMPT | NAMPT, NNMT, NNT | MDM2 4819/4885KDM4E 1401/4885L3MBTL1 3102/4885 |
| US-12091385-B2 | Pyridinylcyanoguanidine derivative and use thereof | NAMPT, NAPRT, NNT | MDM2 3733/4885KDM4E 1773/4885L3MBTL1 2971/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.