SCHEMBL222140

SCHEMBL222140

S=C(S)Nc1ccncc1

nearest known ligand 0.57

Predicted protein targets (top 15)

geneUniProtsupporting neighboursconfidence
MDM2 Q00987 1/20 0.54
EPHX1 P07099 2/20 0.50
KDM4E B2RXH2 1/20 0.48
L3MBTL1 Q9Y468 1/20 0.48
TAAR1 Q96RJ0 2/20 0.47
CTSD P07339 1/20 0.46
MEN1 O00255 2/20 0.44
KMT2A Q03164 2/20 0.44
JAK2 O60674 1/20 0.44
TYK2 P29597 1/20 0.44
GAA P10253 1/20 0.43
LMNA P02545 1/20 0.43
ALDH1A1 P00352 1/20 0.43
BCHE P06276 1/20 0.42
CA9 Q16790 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5548125 0.82 ALDH1A1 (0.48) KDM4EL3MBTL1MEN1KMT2AGAA
SCHEMBL9297614 0.78 MDM2 (0.56) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL1703485 0.76 MDM2 (0.54) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL9297607 0.76 MDM2 (0.67) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL1466506 0.76 MDM2 (0.54) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL526209 0.76 ALDH1A1 (0.60) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL1276484 0.75 ALDH1A1 (0.64) EPHX1KDM4EMEN1KMT2AGAA
SCHEMBL23293647 0.74 PHGDH (0.61) MDM2EPHX1KDM4EL3MBTL1TAAR1
Hydrochloric Acid SCHEMBL31091389 0.74 ALDH1A1 (0.58) MDM2EPHX1KDM4EL3MBTL1TAAR1
SCHEMBL223763 0.74 ATG4B (0.56) KDM4EKMT2ALMNAALDH1A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 25 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
WO-2024142966-A1 POLYMER MECHANORADICAL INITIATOR AND REACTION METHOD USING POLYMER MECHANORADICAL INITIATOR 国立大学法人北海道大学 2024-07-04 WO disclosed
US-20240108736-A1 SELF-ASSEMBLED DIBLOCK COPOLYMERS COMPOSED OF PEGMEMA AND DRUG BEARING POLYMERIC SEGMENTS RS ARASTIRMA EGITIM DANISMANLIK ILAC SANAYI TICARET ANONIM SIRKETI (TR) 2024-04-04 US disclosed
EP-4317197-A1 METHOD FOR PRODUCING POLYMER BY REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION FUJIFILM Corporation (JP) 2024-02-07 EP disclosed
EP-4317204-A1 MANUFACTURING METHOD FOR POLYMER HAVING THIOCARBONYLTHIO GROUP REMOVED FUJIFILM Corporation (JP) 2024-02-07 EP disclosed
US-20230391898-A1 METHOD FOR PRODUCING THIOCARBONYLTHIO GROUP-REMOVED POLYMER FUJIFILM CORPORATION (JP) 2023-12-07 US disclosed
US-20230391896-A1 METHOD FOR PRODUCING REVERSIBLE ADDITION-FRAGMENTATION CHAIN TRANSFER POLYMERIZATION POLYMER FUJIFILM CORPORATION (JP) 2023-12-07 US disclosed
US-11834383-B2 Energetic feedstock for additive manufacturing LYNNTECH, INC. (US) 2023-12-05 US disclosed
EP-4007782-A1 LIPOPHYLIC COPOLYMERS COMPRISING POLAR MULTI-BLOCKS, PROCESS FOR THE PREPARATION THEREOF AND USE IN LUBRICATING COMPOSITIONS ENI S.p.A. (IT) 2022-06-08 EP disclosed
EP-3710061-A1 POLYMER PRODRUGS AND SUBCUTANEOUS AND/OR INTRAMUSCULAR ADMINISTRATION THEREOF Centre National de la Recherche Scientifique (FR) 2020-09-23 EP disclosed
WO-2019164808-A1 POLYMERIZATION PHOTOINHIBITOR THE REGENTS OF THE UNIVERSITY OF MICHIGAN (US) 2019-08-29 WO disclosed
WO-2013060406-A1 SWITCH ELEMENT COMPRISING A LIQUID CRYSTALLINE MEDIUM MERCK PATENT GMBH (DE) 2013-05-02 WO disclosed
CN-102869704-A Non-reactive, hydrophilic polymers having terminal siloxanes and uses of the same JOHNSON & JOHNSON VISION CARE 2013-01-09 CN disclosed
US-20120004381-A1 RAFT POLYMERISATION COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2012-01-05 US disclosed
EP-2389395-A1 RAFT POLYMERISATION Commonwealth Scientific and Industrial Research Organisation (AU) 2011-11-30 EP disclosed
US-20110256644-A1 MASKS FOR MICROLITHOGRAPHY AND METHODS OF MAKING AND USING SUCH MASKS MICRON TECHNOLOGY, INC. (US) 2011-10-20 US disclosed
WO-2010083569-A1 RAFT POLYMERISATION COMMONWEALTH SCIENTIFIC AND INDUSTRIAL RESEARCH ORGANISATION (AU) 2010-07-29 WO disclosed
US-20100184787-A1 Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors ABBVIE DEUTSCHLAND GMBH & CO KG (DE) 2010-07-22 US disclosed
EP-0660823-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS. LEO PHARM PROD LTD (DK) 1995-07-05 EP disclosed
WO-1994006770-A1 N-CYANO-N'-PYRIDYLGUANIDINES AS SEROTONIN ANTAGONISTS Leo Pharmaceutical Products Ltd. A/S (Løvens Kemiske Fabrik Produktionsaktieselskab) (DK) 1994-03-31 WO disclosed
US-4039550-A ANTHELMINTIC AGENTS STERLING DRUG INC. (US) 1977-08-02 US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20120004381-A1 RAFT POLYMERISATION OXGR1, FRG1, MSR1 MDM2 4558/4885EPHX1 847/4885KDM4E 4333/4885
US-20240108736-A1 SELF-ASSEMBLED DIBLOCK COPOLYMERS COMPOSED OF PEGMEMA AND DRUG BEARING POLYMERIC SEGMENTS BCR, EGFR, PBRM1 MDM2 2464/4885EPHX1 1358/4885KDM4E 3873/4885
US-20100184787-A1 Heataryl-substituted guanidine compounds and use thereof as binding partners for 5-ht5-receptors HTR5A, HTR2C, HTR1E MDM2 2139/4885EPHX1 692/4885KDM4E 3290/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.