Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 4/20 | 0.49 |
| ▸ | NPC1 | O15118 | 3/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | PAX8 | Q06710 | 2/20 | 0.49 |
| ▸ | JAK2 | O60674 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.44 |
| ▸ | HSD17B1 | P14061 | 4/20 | 0.44 |
| ▸ | HSD17B2 | P37059 | 4/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | POLB | P06746 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.42 |
| ▸ | PARP1 | P09874 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 2/20 | 0.41 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.41 |
| ▸ | ACHE | P22303 | 1/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1684295 | 0.78 | HSD17B1 (0.57) | RAB9ANPC1ALDH1A1PAX8JAK2 | |
| SCHEMBL30229852 | 0.78 | HSD17B1 (0.57) | RAB9ANPC1ALDH1A1PAX8JAK2 | |
| Ammonia Solution, Strong SCHEMBL28786422 | 0.77 | HSD17B1 (0.55) | RAB9ANPC1ALDH1A1PAX8JAK2 | |
| SCHEMBL11402390 | 0.77 | RAB9A (0.53) | RAB9ANPC1ALDH1A1PAX8JAK2 | |
| SCHEMBL2092268 | 0.77 | RAB9A (0.53) | RAB9ANPC1ALDH1A1PAX8JAK2 | |
| SCHEMBL1006640 | 0.77 | HTR3E (0.43) | RAB9ANPC1ALDH1A1HTTLMNA | |
| SCHEMBL1704182 | 0.77 | CES2 (0.44) | RAB9ANPC1ALDH1A1KMT2APARP1 | |
| SCHEMBL3042400 | 0.77 | NPSR1 (0.50) | RAB9ANPC1ALDH1A1PAX8HTT | |
| SCHEMBL1703740 | 0.77 | MTNR1A (0.50) | RAB9ANPC1LMNAHSD17B1HSD17B2 | |
| SCHEMBL1006925 | 0.76 | CYP3A4 (0.40) | RAB9ANPC1ALDH1A1PAX8JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2558069-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | Novartis AG (CH) | 2013-02-20 | — | — | EP | disclosed |
| EP-2440245-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | Novartis AG (CH) | 2012-04-18 | — | — | EP | disclosed |
| WO-2011130379-A1 | BENZONAPTHYRIDINE COMPOSITIONS AND USES THEREOF | NOVARTIS AG (CH) | 2011-10-20 | — | — | WO | disclosed |
| WO-2010144734-A1 | BENZONAPHTHYRIDINE-CONTAINING VACCINES | NOVARTIS AG (CH) | 2010-12-16 | — | — | WO | disclosed |