Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.49 |
| ▸ | RAB9A | P51151 | 3/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | TP53 | P04637 | 3/20 | 0.48 |
| ▸ | NPC1 | O15118 | 2/20 | 0.48 |
| ▸ | MEN1 | O00255 | 6/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 6/20 | 0.47 |
| ▸ | MAPT | P10636 | 3/20 | 0.47 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.47 |
| ▸ | GAA | P10253 | 1/20 | 0.47 |
| ▸ | EDNRB | P24530 | 1/20 | 0.46 |
| ▸ | EDNRA | P25101 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.44 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.44 |
| ▸ | RELA | Q04206 | 1/20 | 0.44 |
| ▸ | KCNK3 | O14649 | 3/20 | 0.44 |
| ▸ | KCNK9 | Q9NPC2 | 3/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703670 | 0.87 | PKM (0.45) | RAB9ASMN1; SMN2TP53NPC1MEN1 | |
| SCHEMBL1703824 | 0.86 | RAB9A (0.55) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL1704450 | 0.85 | PKM (0.49) | ALDH1A1RAB9ASMN1; SMN2NPC1MEN1 | |
| SCHEMBL1703757 | 0.78 | HPGD (0.48) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL1704322 | 0.77 | MEN1 (0.63) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL5790071 | 0.77 | KIT (0.48) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL1703648 | 0.76 | RAB9A (0.56) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL12496157 | 0.68 | KCNK3 (0.82) | RAB9ASMN1; SMN2NPC1MEN1KMT2A | |
| SCHEMBL6660832 | 0.68 | GRM4 (0.60) | ALDH1A1RAB9ASMN1; SMN2TP53NPC1 | |
| SCHEMBL692386 | 0.68 | HSD17B10 (0.74) | ALDH1A1SMN1; SMN2MEN1KMT2APOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441768-A1 | Thienopyrimidinones for treatment of inflammatory disorders and cancers | Eli Lilly & Co. (US) | 2012-04-18 | — | — | EP | disclosed |