Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.45 |
| ▸ | RXFP1 | Q9HBX9 | 2/20 | 0.44 |
| ▸ | DHODH | Q02127 | 1/20 | 0.44 |
| ▸ | EDNRA | P25101 | 3/20 | 0.43 |
| ▸ | RAB9A | P51151 | 6/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.43 |
| ▸ | RECQL | P46063 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.42 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.42 |
| ▸ | EDNRB | P24530 | 1/20 | 0.42 |
| ▸ | KDM1A | O60341 | 2/20 | 0.41 |
| ▸ | RCOR1 | Q9UKL0 | 2/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704450 | 0.89 | PKM (0.49) | PKMRXFP1EDNRARAB9ANPC1 | |
| SCHEMBL1704052 | 0.87 | ALDH1A1 (0.49) | PKMRXFP1EDNRARAB9ANPC1 | |
| SCHEMBL1703824 | 0.85 | RAB9A (0.55) | PKMRXFP1RAB9ANPC1MAPT | |
| SCHEMBL1703757 | 0.84 | HPGD (0.48) | RXFP1EDNRARAB9ANPC1MAPT | |
| SCHEMBL5790071 | 0.78 | KIT (0.48) | PKMRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1389175 | 0.74 | PKM (0.74) | PKMRAB9ANPC1MAPTSMN1; SMN2 | |
| SCHEMBL1875012 | 0.71 | LMNA (0.37) | RAB9ALMNAHPGD | |
| SCHEMBL1703428 | 0.71 | DHODH (0.51) | PKMRXFP1DHODHRAB9ANPC1 | |
| SCHEMBL17440232 | 0.71 | LMNA (0.37) | RAB9AMEN1KMT2ALMNAHPGD | |
| SCHEMBL2186715 | 0.71 | DHODH (0.63) | PKMRXFP1DHODHRAB9ANPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441768-A1 | Thienopyrimidinones for treatment of inflammatory disorders and cancers | Eli Lilly & Co. (US) | 2012-04-18 | — | — | EP | disclosed |