Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 5/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.48 |
| ▸ | EDNRA | P25101 | 1/20 | 0.44 |
| ▸ | HTT | P42858 | 3/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NPC1 | O15118 | 2/20 | 0.42 |
| ▸ | RAB9A | P51151 | 1/20 | 0.42 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | CISD2 | Q8N5K1 | 1/20 | 0.41 |
| ▸ | PDK1 | Q15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1703670 | 0.84 | PKM (0.45) | HPGDEDNRATP53MAPTNPC1 | |
| SCHEMBL1704450 | 0.80 | PKM (0.49) | EDNRAGAAALDH1A1L3MBTL1MAPT | |
| SCHEMBL1704052 | 0.78 | ALDH1A1 (0.49) | HPGDPOLBEDNRAGAAALDH1A1 | |
| SCHEMBL9259634 | 0.78 | HPGD (0.63) | HPGDPOLBEDNRAHTTGAA | |
| SCHEMBL1703761 | 0.77 | HPGD (0.57) | HPGDPOLBEDNRAHTTGAA | |
| SCHEMBL1704278 | 0.74 | CISD2 (0.53) | HPGDPOLBEDNRAHTTGAA | |
| SCHEMBL1703824 | 0.74 | RAB9A (0.55) | POLBHTTGAAALDH1A1HSD17B10 | |
| SCHEMBL7613280 | 0.73 | EDNRA (0.57) | HPGDPOLBEDNRAHTTGAA | |
| SCHEMBL6005339 | 0.71 | TRPM8 (0.46) | POLBHTTALDH1A1L3MBTL1TP53 | |
| SCHEMBL1875012 | 0.70 | LMNA (0.37) | HPGDGAAALDH1A1L3MBTL1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441768-A1 | Thienopyrimidinones for treatment of inflammatory disorders and cancers | Eli Lilly & Co. (US) | 2012-04-18 | — | — | EP | disclosed |