Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDH2 | P48735 | 1/20 | 0.42 |
| ▸ | RIOK2 | Q9BVS4 | 1/20 | 0.42 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.42 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | SYK | P43405 | 3/20 | 0.40 |
| ▸ | NOS3 | P29474 | 1/20 | 0.39 |
| ▸ | NOS2 | P35228 | 1/20 | 0.39 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.38 |
| ▸ | AURKA | O14965 | 2/20 | 0.38 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.38 |
| ▸ | TEAD1 | P28347 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.38 |
| ▸ | GAA | P10253 | 1/20 | 0.38 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.38 |
| ▸ | PHGDH | O43175 | 1/20 | 0.37 |
| ▸ | KARS1 | Q15046 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704286 | 0.76 | KDR (0.39) | ALDH1A1 | |
| SCHEMBL15829252 | 0.74 | SYK (0.49) | IDH2TAS2R14SYKNOS3NOS2 | |
| SCHEMBL1704454 | 0.74 | KARS1 (0.50) | IDH2RIOK2TAS2R14SYKNOS3 | |
| SCHEMBL1704065 | 0.73 | KARS1 (0.48) | IDH2RIOK2SYKABCG2AURKA | |
| SCHEMBL13726067 | 0.72 | SYK (0.62) | IDH2SYK | |
| SCHEMBL13737619 | 0.72 | NOS3 (0.49) | IDH2SYKNOS3NOS2MAPK1 | |
| SCHEMBL17443159 | 0.72 | IDH2 (0.45) | IDH2RIOK2TAS2R14SYKNOS3 | |
| SCHEMBL16876450 | 0.71 | TAS2R14 (0.51) | IDH2RIOK2TAS2R14SYKNOS3 | |
| SCHEMBL15819732 | 0.70 | SYK (0.46) | IDH2RIOK2SYKNOS3NOS2 | |
| SCHEMBL17536757 | 0.69 | SYK (0.45) | IDH2SYKNOS3NOS2AURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| WO-2012041476-A1 | PYRIDINE AND ISOQUINOLINE DERIVATIVES AS SYK- AND JAK-KINASE INHIBITORS | ALMIRALL, S.A. (ES) | 2012-04-05 | — | — | WO | disclosed |