Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 3/20 | 0.47 |
| ▸ | PRKCH | P24723 | 4/20 | 0.45 |
| ▸ | PRKCE | Q02156 | 4/20 | 0.45 |
| ▸ | SYK | P43405 | 7/20 | 0.39 |
| ▸ | PRKCA | P17252 | 4/20 | 0.39 |
| ▸ | PRKCD | Q05655 | 4/20 | 0.39 |
| ▸ | PRKCB | P05771 | 2/20 | 0.39 |
| ▸ | PRKCQ | Q04759 | 2/20 | 0.39 |
| ▸ | PRKD1 | Q15139 | 2/20 | 0.38 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.38 |
| ▸ | ROCK1 | Q13464 | 1/20 | 0.38 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.38 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.38 |
| ▸ | KDR | P35968 | 1/20 | 0.37 |
| ▸ | SIRT2 | Q8IXJ6 | 1/20 | 0.37 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | ACP1 | P24666 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL902093 | 0.84 | TP53 (0.41) | SIRT2MEN1KMT2AGBA1 | |
| SCHEMBL1704065 | 0.82 | KARS1 (0.48) | KARS1PRKCHPRKCESYKROCK1 | |
| SCHEMBL902681 | 0.80 | KARS1 (0.70) | KARS1KDRMEN1ALDH1A1HPGD | |
| SCHEMBL1704516 | 0.80 | SIRT2 (0.36) | PRKCHSYKPRKCAPRKCDPRKD1 | |
| SCHEMBL30639507 | 0.74 | CHRNA7 (0.50) | KARS1 | |
| SCHEMBL27032743 | 0.74 | CHRNA7 (0.50) | KARS1 | |
| SCHEMBL1704286 | 0.71 | KDR (0.39) | PKN2KDRSIRT2MEN1ALDH1A1 | |
| SCHEMBL902028 | 0.68 | CA12 (0.45) | SYK | |
| SCHEMBL902433 | 0.67 | FDPS (0.43) | PKN2KDRSIRT2MEN1ALDH1A1 | |
| SCHEMBL902035 | 0.67 | KARS1 (0.48) | KARS1SYKSIRT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |