Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.32 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | GCLC | P48506 | 1/20 | 0.31 |
| ▸ | CA2 | P00918 | 1/20 | 0.30 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3167161 | 0.89 | GAA (0.34) | GAAGCLC | |
| SCHEMBL6890549 | 0.85 | CA2 (0.40) | TP53CA2 | |
| SCHEMBL2306366 | 0.85 | CA2 (0.35) | TP53CA2 | |
| SCHEMBL1705128 | 0.83 | GAA (0.32) | TP53GAAGCLCTRPM8 | |
| SCHEMBL152599 | 0.80 | — | — | |
| SCHEMBL3195604 | 0.77 | — | — | |
| SCHEMBL6893526 | 0.77 | CA1 (0.32) | GAA | |
| SCHEMBL31036922 | 0.76 | CA2 (0.36) | TP53CA2 | |
| SCHEMBL28806733 | 0.76 | CA2 (0.36) | TP53CA2 | |
| SCHEMBL2811588 | 0.76 | CA2 (0.36) | TP53CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 19 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9926321-B2 | Hsp90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2018-03-27 | — | — | US | disclosed |
| US-9583272-B2 | Electrolyte solution for electrochemical devices, aluminum electrolytic capacitor, and electric double layer capacitor | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2017-02-28 | — | — | US | disclosed |
| US-20160264577-A1 | HSP90 INHIBITORS | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH | 2016-09-15 | — | — | US | disclosed |
| US-9346808-B2 | Hsp90 inhibitors | SLOAN-KETTERING INSTITUTE FOR CANCER RESEARCH (US) | 2016-05-24 | — | — | US | disclosed |
| US-20150076389-A1 | ELECTROLYTE SOLUTION FOR ELECTROCHEMICAL DEVICES, ALUMINUM ELECTROLYTIC CAPACITOR, AND ELECTRIC DOUBLE LAYER CAPACITOR | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2015-03-19 | — | — | US | disclosed |
| EP-2833381-A1 | ELECTROLYTE SOLUTION FOR ELECTROCHEMICAL DEVICES, ALUMINUM ELECTROLYTIC CAPACITOR, AND ELECTRIC DOUBLE LAYER CAPACITOR | Sumitomo Seika Chemicals Co., Ltd. (JP) | 2015-02-04 | — | — | EP | disclosed |
| US-8664411-B2 | Tetrahydropyranochromene gamma secretase inhibitors | MERCK SHARP & DOHME CORP. (US) | 2014-03-04 | — | — | US | disclosed |
| US-20120136175-A1 | PROCESS FOR PREPARATION OF ALKYL SULFONE COMPOUNDS | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2012-05-31 | — | — | US | disclosed |
| EP-2441751-A1 | PROCESS FOR PREPARATION OF ALKYL SULFONE COMPOUNDS | Sumitomo Seika Chemicals CO. LTD. (JP) | 2012-04-18 | — | — | EP | disclosed |
| US-20110306797-A1 | SULFONE COMPOUND | SUMITOMO SEIKA CHEMICALS CO., LTD. (JP) | 2011-12-15 | — | — | US | disclosed |
| US-20110236400-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION | 2011-09-29 | — | — | US | disclosed |
| US-20110236400-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | SCHERING CORPORATION | 2011-09-29 | — | — | US | disclosed |
| EP-2351735-A1 | SULFONE COMPOUND | Sumitomo Seika Chemicals CO. LTD. (JP) | 2011-08-03 | — | — | EP | disclosed |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | MERCK SHARP & DOHME CORP. | 2011-03-03 | — | — | US | disclosed |
| US-20090181994-A1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2009-07-16 | — | — | US | disclosed |
| US-20090181994-A1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | MERCK & CO., INC. (US) | 2009-07-16 | — | — | US | disclosed |
| US-7504402-B2 | Triazole derivatives as inhibitors of 11-β-hydroxysteroid dehydrogenase-1 | MERCK & CO., INC. (US) | 2009-03-17 | — | — | US | disclosed |
| US-4053526-A | PROCESS FOR ISOLATING DINITRONAPHTHALENES | BAYER AKTIENGESELLSCHAFT (DT) | 1977-10-11 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110306797-A1 | SULFONE COMPOUND | SULT1E1, SULT1A1, STS | TP53 3029/4885GAA 4659/4885GCLC 2034/4885 |
| US-20160264577-A1 | HSP90 INHIBITORS | HSP90AB1, HSP90B1, HSP90AB2P | TP53 165/4885GAA 310/4885GCLC 3326/4885 |
| US-20110054013-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, PSEN1 | TP53 3264/4885GAA 78/4885GCLC 822/4885 |
| US-20120136175-A1 | PROCESS FOR PREPARATION OF ALKYL SULFONE COMPOUNDS | SULT1A1, CBR1, SULT1E1 | TP53 4538/4885GAA 3482/4885GCLC 565/4885 |
| US-20110236400-A1 | TETRAHYDROPYRANOCHROMENE GAMMA SECRETASE INHIBITORS | BACE1, BACE2, APP | TP53 2816/4885GAA 20/4885GCLC 226/4885 |
| US-20090181994-A1 | TRIAZOLE DERIVATIVES AS INHIBITORS OF 11-BETA-HYDROXYSTEROID DEHYDROGENASE-1 | HSD11B1, HSD17B1, HSD3B1 | TP53 4522/4885GAA 773/4885GCLC 3990/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.