Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.56 |
| ▸ | ITK | Q08881 | 2/20 | 0.46 |
| ▸ | AURKA | O14965 | 9/20 | 0.44 |
| ▸ | NTRK1 | P04629 | 3/20 | 0.44 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.42 |
| ▸ | RET | P07949 | 3/20 | 0.42 |
| ▸ | PLK4 | O00444 | 2/20 | 0.42 |
| ▸ | ABL1 | P00519 | 2/20 | 0.42 |
| ▸ | LCK | P06239 | 2/20 | 0.42 |
| ▸ | CSF1R | P07333 | 2/20 | 0.42 |
| ▸ | KIT | P10721 | 2/20 | 0.42 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.42 |
| ▸ | SRC | P12931 | 2/20 | 0.42 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.42 |
| ▸ | TYK2 | P29597 | 2/20 | 0.42 |
| ▸ | KDR | P35968 | 2/20 | 0.42 |
| ▸ | FLT3 | P36888 | 2/20 | 0.42 |
| ▸ | PTK2 | Q05397 | 2/20 | 0.42 |
| ▸ | MAP4K5 | Q9Y4K4 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704773 | 0.88 | KARS1 (0.51) | KARS1RETSYKLRRK2TBK1 | |
| SCHEMBL1704662 | 0.87 | KARS1 (0.72) | KARS1SYK | |
| SCHEMBL1704417 | 0.85 | KARS1 (0.76) | KARS1ITKAURKAAURKBJAK2 | |
| SCHEMBL1704434 | 0.83 | KARS1 (0.68) | KARS1SYK | |
| SCHEMBL902071 | 0.83 | KARS1 (0.72) | KARS1 | |
| SCHEMBL901785 | 0.82 | KARS1 (0.53) | KARS1 | |
| SCHEMBL1704409 | 0.80 | KARS1 (0.73) | KARS1SYK | |
| SCHEMBL901638 | 0.76 | PRKD3 (0.43) | KARS1 | |
| SCHEMBL1704697 | 0.76 | KARS1 (0.71) | KARS1ITK | |
| SCHEMBL901697 | 0.75 | KARS1 (0.65) | KARS1SYKTBK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |