Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KARS1 | Q15046 | 6/20 | 0.66 |
| ▸ | HTR7 | P34969 | 5/20 | 0.52 |
| ▸ | HTR1A | P08908 | 4/20 | 0.52 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.48 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | CDK9 | P50750 | 1/20 | 0.47 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.47 |
| ▸ | PLK4 | O00444 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ADRB1 | P08588 | 1/20 | 0.45 |
| ▸ | AURKA | O14965 | 3/20 | 0.45 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.45 |
| ▸ | ITK | Q08881 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1704417 | 0.84 | KARS1 (0.76) | KARS1JAK2AURKAAURKBITK | |
| SCHEMBL901632 | 0.79 | KARS1 (1.00) | KARS1HTR7HTR1ACAMK2D | |
| SCHEMBL1704501 | 0.78 | HTR2C (0.45) | KARS1PLK4PAK4AURKAAURKB | |
| SCHEMBL901727 | 0.76 | KARS1 (1.00) | KARS1HTR7HTR1ACAMK2DADRB1 | |
| SCHEMBL902609 | 0.75 | HTR2C (0.44) | KARS1AURKAAURKBITK | |
| SCHEMBL902289 | 0.73 | ITK (0.54) | KARS1AURKAAURKBITK | |
| SCHEMBL1704696 | 0.71 | KARS1 (0.67) | KARS1HTR7JAK2CDK9CDK5 | |
| SCHEMBL1704457 | 0.71 | ITK (0.55) | KARS1AURKAAURKBITK | |
| SCHEMBL8257041 | 0.70 | HTR7 (0.56) | KARS1HTR7HTR1ACAMK2DADRB1 | |
| SCHEMBL22534378 | 0.70 | PLK4 (0.61) | JAK2PLK4PAK4AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | claimed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |
| EP-2441755-A1 | Pyridine- and isoquinoline-derivatives as Syk and JAK kinase inhibitors | Almirall, S.A. (ES) | 2012-04-18 | — | — | EP | disclosed |