Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SCN9A | Q15858 | 10/20 | 0.50 |
| ▸ | SCN2B | O60939 | 1/20 | 0.50 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.50 |
| ▸ | PARG | Q86W56 | 2/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.37 |
| ▸ | SCN1A | P35498 | 5/20 | 0.37 |
| ▸ | SCN5A | Q14524 | 5/20 | 0.37 |
| ▸ | SCN8A | Q9UQD0 | 5/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1095058 | 0.81 | PKM (0.49) | SCN9ASCN2BSCN1B | |
| SCHEMBL17048677 | 0.79 | HSD11B1 (0.40) | SCN9ASCN2BSCN1BHSD11B1SCN1A | |
| SCHEMBL18882721 | 0.78 | SCN9A (0.48) | SCN9ASCN2BSCN1BSCN1ASCN5A | |
| SCHEMBL29514234 | 0.75 | SCN9A (0.51) | SCN9ASCN2BSCN1B | |
| SCHEMBL17048577 | 0.75 | SCN9A (0.51) | SCN9ASCN2BSCN1B | |
| SCHEMBL1094819 | 0.73 | L3MBTL1 (0.55) | SCN9A | |
| SCHEMBL29669015 | 0.73 | SCN9A (0.59) | SCN9ASCN2BSCN1BSCN1ASCN5A | |
| SCHEMBL20238716 | 0.73 | SCN9A (0.59) | SCN9ASCN2BSCN1BSCN1ASCN5A | |
| SCHEMBL3475966 | 0.71 | ALDH1A1 (0.54) | SCN9A | |
| SCHEMBL5391658 | 0.71 | MAPT (0.56) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11236078-B2 | Heterocyclic inhibitors of the sodium channel | DeGiacomo, Mark G. (US) | 2022-02-01 | — | — | US | disclosed |
| US-11236078-B2 | Heterocyclic inhibitors of the sodium channel | DeGiacomo, Mark G. (US) | 2022-02-01 | — | — | US | disclosed |
| US-20170145003-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | DeGiacomo, Mark G. (US) | 2017-05-25 | — | — | US | disclosed |
| US-20170145003-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | DeGiacomo, Mark G. (US) | 2017-05-25 | — | — | US | disclosed |
| US-20170145003-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | DeGiacomo, Mark G. (US) | 2017-05-25 | — | — | US | disclosed |
| WO-2015130957-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | Zalicus Pharmaceuticals, Ltd. (US) | 2015-09-03 | — | — | WO | disclosed |
| WO-2015130957-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | Zalicus Pharmaceuticals, Ltd. (US) | 2015-09-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20170145003-A1 | HETEROCYCLIC INHIBITORS OF THE SODIUM CHANNEL | SCN1B, SCN1A, CACNA1S | SCN9A 29/4885SCN2B 15/4885SCN1B 1/4885 |
| US-11236078-B2 | Heterocyclic inhibitors of the sodium channel | SCN1B, TRPM6, SCN1A | SCN9A 32/4885SCN2B 13/4885SCN1B 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.