Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.57 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.57 |
| ▸ | RAB9A | P51151 | 3/20 | 0.57 |
| ▸ | BRD4 | O60885 | 4/20 | 0.55 |
| ▸ | BRD9 | Q9H8M2 | 3/20 | 0.55 |
| ▸ | KAT2B | Q92831 | 2/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CNR2 | P34972 | 4/20 | 0.52 |
| ▸ | CNR1 | P21554 | 1/20 | 0.49 |
| ▸ | BPTF | Q12830 | 3/20 | 0.48 |
| ▸ | HTT | P42858 | 5/20 | 0.48 |
| ▸ | NPSR1 | Q6W5P4 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | NPBWR1 | P48145 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 2/20 | 0.46 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17074602 | 0.80 | RAB9A (0.85) | SMN1; SMN2KDM4ERAB9ABRD4BRD9 | |
| SCHEMBL11004228 | 0.79 | BRD4 (0.56) | SMN1; SMN2KDM4ERAB9ABRD4BRD9 | |
| SCHEMBL17074604 | 0.78 | CNR2 (0.54) | SMN1; SMN2KDM4ERAB9ABRD4BRD9 | |
| SCHEMBL18454995 | 0.76 | HTT (0.59) | SMN1; SMN2KDM4ERAB9ABRD4ALDH1A1 | |
| SCHEMBL1691901 | 0.75 | HTT (0.71) | SMN1; SMN2KDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL27077676 | 0.73 | KMT2A (0.50) | SMN1; SMN2KDM4ERAB9ABRD4BRD9 | |
| SCHEMBL8963991 | 0.73 | HTT (0.59) | SMN1; SMN2KDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL22989953 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2KDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL4799238 | 0.73 | ALDH1A1 (0.52) | SMN1; SMN2KDM4ERAB9AALDH1A1MAPT | |
| SCHEMBL9239743 | 0.73 | HTT (0.52) | SMN1; SMN2KDM4ERAB9AALDH1A1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2957560-A1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN, INC. (US) | 2015-12-23 | — | — | EP | disclosed |
| EP-2534137-B1 | PYRIDAZINE DERIVATIVES USEFUL AS CANNABINOID-2 AGONISTS | ALLERGAN INC (US) | 2015-09-16 | — | — | EP | disclosed |