Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 7/20 | 0.75 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.75 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.56 |
| ▸ | RAB9A | P51151 | 6/20 | 0.56 |
| ▸ | NPC1 | O15118 | 6/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | HTT | P42858 | 2/20 | 0.51 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.48 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.48 |
| ▸ | RELA | Q04206 | 1/20 | 0.48 |
| ▸ | ATM | Q13315 | 1/20 | 0.48 |
| ▸ | TP53 | P04637 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708514 | 0.89 | SMN1; SMN2 (0.62) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1708448 | 0.89 | KDM4E (0.62) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1707835 | 0.87 | SMN1; SMN2 (0.59) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1708521 | 0.86 | SMN1; SMN2 (0.58) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL15120766 | 0.80 | HSD17B10 (0.68) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL1708278 | 0.76 | SMN1; SMN2 (0.56) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL16383886 | 0.75 | SMN1; SMN2 (0.77) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL4603679 | 0.75 | SMN1; SMN2 (0.74) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL17712428 | 0.74 | SMN1; SMN2 (0.71) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD | |
| SCHEMBL8667637 | 0.72 | RAB9A (0.75) | SMN1; SMN2KDM4EALDH1A1HSD17B10HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20120172351-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2012-07-05 | — | — | US | disclosed |
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120172351-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | GPR119, INSR, GLP1R | SMN1; SMN2 4287/4885KDM4E 3896/4885ALDH1A1 3930/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.