Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A2 | P23975 | 7/20 | 0.50 |
| ▸ | SLC6A4 | P31645 | 5/20 | 0.50 |
| ▸ | SLC6A3 | Q01959 | 5/20 | 0.50 |
| ▸ | HTR1A | P08908 | 4/20 | 0.50 |
| ▸ | HTR2B | P41595 | 3/20 | 0.50 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.50 |
| ▸ | HTR2A | P28223 | 1/20 | 0.50 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.47 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.46 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.46 |
| ▸ | ALOX5AP | P20292 | 3/20 | 0.46 |
| ▸ | FEN1 | P39748 | 3/20 | 0.46 |
| ▸ | HTR2C | P28335 | 3/20 | 0.44 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.44 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.44 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.44 |
| ▸ | IKBKB | O14920 | 1/20 | 0.44 |
| ▸ | CHUK | O15111 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17077450 | 1.00 | SLC6A2 (0.50) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL23582983 | 0.99 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL17077567 | 0.99 | SLC6A2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Tert-Butyl Formate SCHEMBL28099269 | 0.88 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Tert-Butyl Formate SCHEMBL28099271 | 0.88 | SLC6A2 (0.41) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Cadaverine Tartrate SCHEMBL17077537 | 0.88 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Cadaverine Tartrate SCHEMBL17077538 | 0.88 | SLC6A2 (0.43) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| SCHEMBL4247388 | 0.81 | HRH1 (0.57) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL23582336 | 0.81 | CHRNB2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B | |
| Hydrochloric Acid SCHEMBL23582338 | 0.81 | CHRNB2 (0.49) | SLC6A2SLC6A4SLC6A3HTR1AHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 12 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4074701-A1 | NOVEL AMIDE DERIVATIVE USEFUL AS DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITOR, AND USE THEREOF | Lg Chem, Ltd. (KR) | 2022-10-19 | — | — | EP | disclosed |
| CN-114901653-A | Novel amide derivatives useful as diacylglycerol acyltransferase 2 inhibitors and uses thereof | 株式会社LG化学 | 2022-08-12 | — | — | CN | disclosed |
| WO-2021161222-A1 | COMPOUNDS USEFUL IN INHIBITING DIACYLGLYCEROL O-ACYLTRANSFERASE AND METHODS OF MAKING AND USING THE SAME | INORBIT THERAPEUTICS AB (SE) | 2021-08-19 | — | — | WO | disclosed |
| WO-2021161222-A1 | COMPOUNDS USEFUL IN INHIBITING DIACYLGLYCEROL O-ACYLTRANSFERASE AND METHODS OF MAKING AND USING THE SAME | INORBIT THERAPEUTICS AB (SE) | 2021-08-19 | — | — | WO | disclosed |
| US-10188653-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2019-01-29 | — | — | US | disclosed |
| EP-3119757-B1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS FOR USE IN THE TREATMENT OF METABOLIC AND RELATED DISORDERS | PFIZER (US) | 2018-05-16 | — | — | EP | disclosed |
| US-20180042926-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2018-02-15 | — | — | US | disclosed |
| US-9789110-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2017-10-17 | — | — | US | disclosed |
| CN-106103425-A | Diacylglycerol acyltransferase 2 inhibitors for the treatment of metabolic and related disorders | 辉瑞公司 | 2016-11-09 | — | — | CN | disclosed |
| US-20160303125-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2016-10-20 | — | — | US | disclosed |
| US-9440949-B2 | Diacylglycerol acyltransferase 2 inhibitors | PFIZER INC. (US) | 2016-09-13 | — | — | US | disclosed |
| US-20150259323-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | PFIZER INC. (US) | 2015-09-17 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (4 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150259323-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | SLC6A2 1542/4885SLC6A4 3480/4885SLC6A3 2116/4885 |
| US-10188653-B2 | Diacylglycerol acyltransferase 2 inhibitors | DGAT2, LCLAT1, DGAT1 | SLC6A2 1542/4885SLC6A4 3480/4885SLC6A3 2116/4885 |
| US-20160303125-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | SLC6A2 1542/4885SLC6A4 3480/4885SLC6A3 2116/4885 |
| US-20180042926-A1 | DIACYLGLYCEROL ACYLTRANSFERASE 2 INHIBITORS | DGAT2, LCLAT1, DGAT1 | SLC6A2 1542/4885SLC6A4 3480/4885SLC6A3 2116/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.