Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.57 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | CA1 | P00915 | 1/20 | 0.52 |
| ▸ | CA2 | P00918 | 1/20 | 0.52 |
| ▸ | CA5A | P35218 | 1/20 | 0.52 |
| ▸ | CA9 | Q16790 | 1/20 | 0.52 |
| ▸ | MAPT | P10636 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 1/20 | 0.51 |
| ▸ | GAA | P10253 | 1/20 | 0.51 |
| ▸ | SLC40A1 | Q9NP59 | 1/20 | 0.49 |
| ▸ | BRD4 | O60885 | 3/20 | 0.48 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.48 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.48 |
| ▸ | PTPN5 | P54829 | 1/20 | 0.48 |
| ▸ | IDH1 | O75874 | 1/20 | 0.43 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
| ▸ | MMP13 | P45452 | 1/20 | 0.42 |
| ▸ | TP53 | P04637 | 1/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2741010 | 0.83 | NPC1 (0.66) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL17078013 | 0.82 | IDH1 (0.53) | IDH1TP53HSD17B10 | |
| SCHEMBL19182212 | 0.82 | CCKBR (0.43) | KMT2AMEN1MAPTBRD4IDH1 | |
| SCHEMBL30014317 | 0.79 | BRD4 (0.50) | KMT2AMEN1SLC40A1BRD4PTPN2 | |
| SCHEMBL96178 | 0.78 | KMT2A (0.63) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL12167785 | 0.78 | MMP2 (0.67) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL14150131 | 0.78 | MEN1 (0.63) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL19180007 | 0.76 | SLC40A1 (0.56) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL15482267 | 0.75 | MMP2 (0.60) | KMT2AMEN1CA1CA2CA5A | |
| SCHEMBL14106146 | 0.75 | KMT2A (0.59) | KMT2AMEN1CA1CA2CA5A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 15 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | KURES, INC. | 2024-03-21 | — | — | US | disclosed |
| EP-3116509-B1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | UNIV COLUMBIA (US) | 2022-06-22 | — | — | EP | disclosed |
| EP-3116509-B1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | UNIV COLUMBIA (US) | 2022-06-22 | — | — | EP | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2022-04-07 | — | — | US | disclosed |
| CN-106535901-B | Mu-opioid receptor agonists | 哥伦比亚大学董事会 | 2020-03-31 | — | — | CN | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-03-21 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-10183919-B2 | Class of mu-opioid receptor agonists | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2019-01-22 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2017-08-03 | — | — | US | disclosed |
| EP-3116509-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | The Trustees of Columbia University in the City of New York (US) | 2017-01-18 | — | — | EP | disclosed |
| WO-2015138791-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) | 2015-09-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240092802-A1 | MU-OPIOID RECEPTOR AGONISTS AND USES THEREFOR | OPRL1, OPRM1, CDKL5 | KMT2A 203/4885MEN1 3488/4885CA1 4222/4885 |
| US-10183919-B2 | Class of mu-opioid receptor agonists | OPRM1, OPRL1, OPRK1 | KMT2A 1768/4885MEN1 4601/4885CA1 3391/4885 |
| US-20220106279-A1 | CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | KMT2A 1768/4885MEN1 4601/4885CA1 3391/4885 |
| US-20190084949-A1 | NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | KMT2A 1847/4885MEN1 4732/4885CA1 4040/4885 |
| US-20170217913-A1 | A NEW CLASS OF MU-OPIOID RECEPTOR AGONISTS | OPRM1, OPRL1, OPRK1 | KMT2A 1796/4885MEN1 4738/4885CA1 4029/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.