Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | MEN1 | O00255 | 4/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.36 |
| ▸ | GAA | P10253 | 3/20 | 0.36 |
| ▸ | USP2 | O75604 | 2/20 | 0.36 |
| ▸ | CASP1 | P29466 | 2/20 | 0.36 |
| ▸ | HBB | P68871 | 2/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.35 |
| ▸ | INSR | P06213 | 1/20 | 0.34 |
| ▸ | IGF1R | P08069 | 1/20 | 0.34 |
| ▸ | TSHR | P16473 | 3/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.34 |
| ▸ | RAB9A | P51151 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708070 | 0.94 | LMNA (0.40) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1708268 | 0.92 | SMN1; SMN2 (0.35) | MAPTMEN1KMT2AGAALMNA | |
| SCHEMBL1708303 | 0.92 | SMN1; SMN2 (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1708180 | 0.88 | SMN1; SMN2 (0.40) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1708036 | 0.87 | INSR (0.35) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1708109 | 0.85 | FFAR1 (0.37) | MAPTALDH1A1MEN1KMT2AKDM4E | |
| SCHEMBL1708280 | 0.85 | FFAR1 (0.42) | — | |
| SCHEMBL1707879 | 0.85 | MAPT (0.34) | MAPTLMNASMN1; SMN2INSRIGF1R | |
| SCHEMBL1708250 | 0.85 | ALDH1A1 (0.34) | MAPTALDH1A1MEN1KMT2AGAA | |
| SCHEMBL1708297 | 0.85 | TSHR (0.38) | MAPTALDH1A1GAALMNASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |