Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BMI1 | P35226 | 3/20 | 0.33 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.32 |
| ▸ | NPC1 | O15118 | 2/20 | 0.31 |
| ▸ | RAB9A | P51151 | 2/20 | 0.31 |
| ▸ | PDE2A | O00408 | 2/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 3/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.30 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.30 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TP53 | P04637 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708080 | 0.93 | NPC1 (0.35) | BMI1NPC1RAB9APDE2AMAPT | |
| SCHEMBL1707997 | 0.91 | PDE2A (0.33) | NPC1RAB9APDE2ANTRK1NTRK2 | |
| SCHEMBL1708155 | 0.91 | NTRK1 (0.37) | NPC1RAB9ANTRK1NTRK2MAPT | |
| SCHEMBL1708298 | 0.91 | PDE10A (0.33) | NPC1RAB9APDE2AMAPTKDM4E | |
| SCHEMBL1708150 | 0.87 | NPC1 (0.39) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL1708438 | 0.86 | GFER (0.38) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL1708134 | 0.86 | INSR (0.30) | NPC1RAB9ANTRK1NTRK2GAA | |
| SCHEMBL1707879 | 0.85 | MAPT (0.34) | BMI1HDAC6NPC1RAB9APDE2A | |
| SCHEMBL1708106 | 0.85 | NPC1 (0.35) | NPC1RAB9AMAPTKDM4EMEN1 | |
| SCHEMBL1708122 | 0.85 | MAPT (0.33) | BMI1HDAC6NPC1RAB9APDE2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |