Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | INSR | P06213 | 1/20 | 0.30 |
| ▸ | IGF1R | P08069 | 1/20 | 0.30 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.30 |
| ▸ | NTRK2 | Q16620 | 1/20 | 0.30 |
| ▸ | NPC1 | O15118 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | THRB | P10828 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708155 | 0.90 | NTRK1 (0.37) | NTRK1NTRK2NPC1GAARAB9A | |
| SCHEMBL1707997 | 0.86 | PDE2A (0.33) | NTRK1NTRK2NPC1RAB9ATHRB | |
| SCHEMBL1708026 | 0.86 | BMI1 (0.33) | NTRK1NTRK2NPC1GAARAB9A | |
| SCHEMBL1708438 | 0.85 | GFER (0.38) | NPC1GAARAB9AL3MBTL1 | |
| SCHEMBL1708363 | 0.85 | INSR (0.34) | INSRIGF1RNTRK1NTRK2NPC1 | |
| SCHEMBL1708254 | 0.85 | MAPT (0.37) | INSRIGF1RNPC1GAARAB9A | |
| SCHEMBL1708631 | 0.84 | NPC1 (0.35) | NTRK1NTRK2NPC1GAARAB9A | |
| SCHEMBL1708244 | 0.83 | NPC1 (0.32) | INSRIGF1RNPC1RAB9A | |
| SCHEMBL1708111 | 0.82 | NPC1 (0.33) | NTRK1NTRK2NPC1GAARAB9A | |
| SCHEMBL1708162 | 0.82 | MAPT (0.34) | NTRK1NTRK2NPC1GAARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |