Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALOX5AP | P20292 | 9/20 | 0.33 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.32 |
| ▸ | TRPV1 | Q8NER1 | 2/20 | 0.32 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.31 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.31 |
| ▸ | SCN9A | Q15858 | 1/20 | 0.31 |
| ▸ | CTSL | P07711 | 2/20 | 0.31 |
| ▸ | CTSS | P25774 | 2/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.31 |
| ▸ | IDH1 | O75874 | 2/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708368 | 0.91 | LMNA (0.33) | MDM2TRPV1 | |
| SCHEMBL1708060 | 0.90 | MAPT (0.32) | TRPV1 | |
| SCHEMBL1708304 | 0.90 | MAPT (0.32) | — | |
| SCHEMBL10291391 | 0.89 | FFAR1 (0.39) | — | |
| SCHEMBL10011833 | 0.89 | FFAR1 (0.39) | — | |
| SCHEMBL1708237 | 0.89 | APLNR (0.34) | — | |
| SCHEMBL1708420 | 0.89 | L3MBTL1 (0.36) | — | |
| SCHEMBL10291555 | 0.89 | FFAR1 (0.37) | CYP2D6IDH1 | |
| SCHEMBL1708037 | 0.87 | FFAR1 (0.33) | ALOX5APCYP2D6TRPV1IDH1 | |
| SCHEMBL3794538 | 0.82 | CYP2D6 (0.32) | ALOX5APCYP2D6IDH1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |