Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 4/20 | 0.32 |
| ▸ | TP53 | P04637 | 2/20 | 0.32 |
| ▸ | APLNR | P35414 | 9/20 | 0.32 |
| ▸ | BRD4 | O60885 | 1/20 | 0.31 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.31 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.31 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.30 |
| ▸ | DHFR | P00374 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.30 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.30 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1708304 | 0.94 | MAPT (0.32) | MAPTTP53APLNRBRD4CREBBP | |
| SCHEMBL1708237 | 0.92 | APLNR (0.34) | MAPTAPLNRBRD4CREBBPMCHR1 | |
| SCHEMBL1708420 | 0.92 | L3MBTL1 (0.36) | MAPTTP53APLNRMCHR1ALDH1A1 | |
| SCHEMBL1708368 | 0.92 | LMNA (0.33) | MAPTGAAHTTSMN1; SMN2TRPV1 | |
| SCHEMBL1708079 | 0.90 | ALOX5AP (0.33) | TRPV1 | |
| SCHEMBL10009394 | 0.88 | FFAR1 (0.39) | MAPTTP53 | |
| SCHEMBL10292326 | 0.88 | FFAR1 (0.39) | MAPTTP53 | |
| SCHEMBL10291238 | 0.87 | FFAR1 (0.35) | MAPTTP53APLNR | |
| SCHEMBL10010762 | 0.82 | FFAR1 (0.39) | MAPT | |
| SCHEMBL3791750 | 0.81 | DHFR (0.33) | MAPTTP53APLNRDHFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2440541-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | Takeda Pharmaceutical Company Limited (JP) | 2012-04-18 | — | — | EP | disclosed |
| WO-2010143733-A1 | NOVEL FUSED CYCLIC COMPOUND AND USE THEREOF | TAKEDA PHARMACEUTICAL COMPANY LIMITED (JP) | 2010-12-16 | — | — | WO | disclosed |