Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | MEN1 | O00255 | 2/20 | 0.31 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.31 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.31 |
| ▸ | TSHR | P16473 | 1/20 | 0.31 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.31 |
| ▸ | THPO | P40225 | 1/20 | 0.31 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.31 |
| ▸ | GRM5 | P41594 | 1/20 | 0.31 |
| ▸ | GRIA1 | P42261 | 1/20 | 0.31 |
| ▸ | GRIA2 | P42262 | 1/20 | 0.31 |
| ▸ | GRIA3 | P42263 | 1/20 | 0.31 |
| ▸ | GRIA4 | P48058 | 1/20 | 0.31 |
| ▸ | BLM | P54132 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927992 | 0.77 | HSD11B1 (0.44) | HSD11B1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL8836934 | 0.73 | GABRR1 (0.36) | — | |
| SCHEMBL5966273 | 0.72 | TSHR (0.33) | HSD11B1TSHRSLC6A12SLC6A11SLC6A13 | |
| SCHEMBL6427735 | 0.71 | SLC6A12 (0.43) | HSD11B1AKR1C4AKR1C3AKR1C2LMNA | |
| SCHEMBL11556130 | 0.70 | SLC6A12 (0.35) | AKR1C4AKR1C3AKR1C2MEN1KMT2A | |
| SCHEMBL2482028 | 0.70 | MEN1 (0.32) | MEN1KMT2AALDH1A1 | |
| SCHEMBL20142223 | 0.67 | SLC6A12 (0.43) | HSD11B1AKR1C4AKR1C3AKR1C2SLC6A12 | |
| SCHEMBL15544333 | 0.67 | HSD11B1 (0.41) | HSD11B1MEN1KMT2AMAPK1TSHR | |
| SCHEMBL2848938 | 0.67 | GABRR1 (0.38) | HSD11B1SLC6A12SLC6A11SLC6A13 | |
| SCHEMBL9406866 | 0.66 | ANPEP (0.43) | KMT2AALDH1A1LMNASLC6A12SLC6A11 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2054368-B1 | CYCLIC 11-BETA HYDROXYSTEROID DEHYDROGENASE TYPE I INHIBITORS | BRISTOL MYERS SQUIBB CO (US) | 2015-09-16 | — | — | EP | disclosed |