Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC6A12 | P48065 | 5/20 | 0.43 |
| ▸ | SLC6A13 | Q9NSD5 | 5/20 | 0.43 |
| ▸ | SLC6A11 | P48066 | 4/20 | 0.43 |
| ▸ | GABRR1 | P24046 | 8/20 | 0.33 |
| ▸ | GABRA5 | P31644 | 6/20 | 0.33 |
| ▸ | GABRB2 | P47870 | 6/20 | 0.33 |
| ▸ | GABRR2 | P28476 | 1/20 | 0.33 |
| ▸ | PLG | P00747 | 1/20 | 0.32 |
| ▸ | PLAT | P00750 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.32 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.32 |
| ▸ | AKR1C4 | P17516 | 1/20 | 0.32 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.32 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 3/20 | 0.31 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.31 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.31 |
| ▸ | SLC6A1 | P30531 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1927992 | 0.78 | HSD11B1 (0.44) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL20142223 | 0.77 | SLC6A12 (0.43) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL19032979 | 0.76 | SLC6A12 (0.52) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL2848938 | 0.76 | GABRR1 (0.38) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL13992044 | 0.75 | SLC6A12 (0.41) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL5966273 | 0.74 | TSHR (0.33) | SLC6A12SLC6A13SLC6A11HSD11B1 | |
| SCHEMBL9278180 | 0.72 | SLC6A12 (0.57) | SLC6A12SLC6A13SLC6A11GABRR1GABRA5 | |
| SCHEMBL24772368 | 0.72 | NOS3 (0.31) | — | |
| SCHEMBL1861904 | 0.71 | — | — | |
| SCHEMBL12993394 | 0.71 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0994704-B1 | USE OF GABA ANALOGS SUCH AS GABAPENTIN IN THE MANUFACTURE OF A MEDICAMENT FOR TREATING INFLAMMATORY DISEASES | WARNER LAMBERT CO (US) | 2005-06-15 | — | — | EP | claimed |