Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TRPM5 | Q9NZQ8 | 1/20 | 0.40 |
| ▸ | CNR2 | P34972 | 4/20 | 0.37 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | DRD2 | P14416 | 3/20 | 0.36 |
| ▸ | HTR2A | P28223 | 3/20 | 0.36 |
| ▸ | DRD3 | P35462 | 3/20 | 0.36 |
| ▸ | NPY5R | Q15761 | 2/20 | 0.35 |
| ▸ | MCHR1 | Q99705 | 2/20 | 0.35 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.34 |
| ▸ | HTR6 | P50406 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.33 |
| ▸ | ALDH3A1 | P30838 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11934893 | 1.00 | TRPM5 (0.40) | TRPM5CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL11936277 | 0.92 | LMNA (0.40) | CNR2NPC1RAB9ASMN1; SMN2MET | |
| SCHEMBL11935138 | 0.85 | TRPM5 (0.40) | TRPM5CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17090388 | 0.85 | TRPM5 (0.40) | TRPM5CNR2NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13565452 | 0.81 | DRD2 (0.39) | CNR2METDRD2HTR2ADRD3 | |
| SCHEMBL17090004 | 0.81 | DRD2 (0.39) | CNR2METDRD2HTR2ADRD3 | |
| SCHEMBL10113354 | 0.80 | NPY5R (0.52) | NPC1RAB9ASMN1; SMN2NPY5RALDH1A1 | |
| SCHEMBL13203873 | 0.80 | NPY5R (0.52) | NPC1RAB9ASMN1; SMN2NPY5RALDH1A1 | |
| SCHEMBL17090126 | 0.79 | ALDH1A1 (0.42) | TRPM5CNR2SMN1; SMN2METDRD2 | |
| SCHEMBL13565133 | 0.79 | ALDH1A1 (0.42) | TRPM5CNR2SMN1; SMN2METDRD2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |