Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM1A | O60341 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | CACNA1H | O95180 | 2/20 | 0.39 |
| ▸ | NPY5R | Q15761 | 1/20 | 0.39 |
| ▸ | CRHR1 | P34998 | 3/20 | 0.39 |
| ▸ | MAPK14 | Q16539 | 3/20 | 0.36 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | CA2 | P00918 | 1/20 | 0.36 |
| ▸ | USP2 | O75604 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17090128 | 0.87 | MEN1 (0.43) | LMNANPY5RCRHR1CNR1CNR2 | |
| SCHEMBL13565746 | 0.87 | MEN1 (0.43) | LMNANPY5RCRHR1CNR1CNR2 | |
| SCHEMBL13438995 | 0.87 | MAPK14 (0.46) | NPY5RCRHR1MAPK14CNR1CNR2 | |
| SCHEMBL17090170 | 0.87 | KDM1A (0.39) | KDM1ALMNAHTTCACNA1HNPY5R | |
| SCHEMBL11935305 | 0.87 | MAPK14 (0.46) | NPY5RCRHR1MAPK14CNR1CNR2 | |
| SCHEMBL11935324 | 0.86 | LMNA (0.53) | LMNACRHR1MAPK14HSPB1CYP2C9 | |
| SCHEMBL17090231 | 0.86 | LMNA (0.53) | LMNACRHR1MAPK14HSPB1CYP2C9 | |
| SCHEMBL17090516 | 0.85 | CRHR1 (0.47) | LMNANPY5RCRHR1MAPK14MAPK11 | |
| SCHEMBL17090363 | 0.84 | HTT (0.44) | HTTNPY5RCRHR1MAPK14POLB | |
| SCHEMBL13565142 | 0.83 | NPY5R (0.42) | NPY5RCRHR1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |