Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.49 |
| ▸ | MAPK14 | Q16539 | 4/20 | 0.48 |
| ▸ | NPC1 | O15118 | 4/20 | 0.47 |
| ▸ | RAB9A | P51151 | 4/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.46 |
| ▸ | CA12 | O43570 | 1/20 | 0.45 |
| ▸ | CA1 | P00915 | 1/20 | 0.45 |
| ▸ | CA9 | Q16790 | 1/20 | 0.45 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.43 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.43 |
| ▸ | PTPN11 | Q06124 | 1/20 | 0.43 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11935324 | 1.00 | LMNA (0.53) | LMNAKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL13439007 | 0.88 | CRHR1 (0.55) | LMNAKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL11935327 | 0.88 | CRHR1 (0.55) | LMNAKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL13438995 | 0.86 | MAPK14 (0.46) | KMT2AMAPK14CRHR1ALDH1A1NAMPT | |
| SCHEMBL11935305 | 0.86 | MAPK14 (0.46) | KMT2AMAPK14CRHR1ALDH1A1NAMPT | |
| SCHEMBL17090002 | 0.86 | KDM1A (0.40) | LMNAKMT2AMAPK14CRHR1HSPB1 | |
| SCHEMBL17090417 | 0.85 | LMNA (0.53) | LMNAKMT2AMAPK14NPC1RAB9A | |
| SCHEMBL17090128 | 0.84 | MEN1 (0.43) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL13565746 | 0.84 | MEN1 (0.43) | LMNAKMT2ANPC1RAB9ASMN1; SMN2 | |
| SCHEMBL17090356 | 0.82 | ALDH1A1 (0.53) | LMNAKMT2ASMN1; SMN2HPGDALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-9139518-B2 | Amine derivative having NPY Y5 receptor antagonistic activity | SHIONOGI & CO., LTD. (JP) | 2015-09-22 | — | — | US | disclosed |